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Light-Mediated Liberation of Enzymatic Activity: "Small Molecule" Caged Protein Equivalents

Title
Light-Mediated Liberation of Enzymatic Activity: "Small Molecule" Caged Protein Equivalents
Author
하정미
Keywords
CATALYTIC SUBUNIT; TYROSINE KINASES; ACQUISITION
Issue Date
2008-07
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v. 130, No. 32, Page. 10474-10475
Abstract
Light-activatable ("caged") proteins have been used to correlate, with exquisite temporal and spatial control, intracellular biochemical action with global cellular behavior. However, the chemical or genetic construction of caged proteins is nontrivial, with subsequent laborious introduction into living cells, potentially problematic competition with natural endogenous counterparts, and challenging intracellular incorporation at levels equivalent to the natural enzymes. We describe the design, synthesis, and characterization of small molecular equivalents of a caged Src kinase. These compounds are easy to prepare and function by inhibiting the action of the natural unmodified enzyme.
URI
https://pubs.acs.org/doi/abs/10.1021/ja803395dhttp://repository.hanyang.ac.kr/handle/20.500.11754/104717
ISSN
0002-7863
DOI
10.1021/ja803395d
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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