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dc.contributor.author최한곤-
dc.date.accessioned2019-05-17T01:04:42Z-
dc.date.available2019-05-17T01:04:42Z-
dc.date.issued2008-04-
dc.identifier.citationCHEMICAL & PHARMACEUTICAL BULLETIN, v. 56, No. 4, Page. 569-574en_US
dc.identifier.issn0009-2363-
dc.identifier.urihttps://www.jstage.jst.go.jp/article/cpb/56/4/56_4_569/_article/-char/ja/-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/104468-
dc.description.abstractTo improve its solubility, dissolution, and bioavailability; Ibuprofen-polyethylene glycol 8000 (PEG 8000) solid dispersions (SDs) with different drug loadings were prepared, characterized by scanning electron microscopy (SEM) and differential scanning calorimetry(DSC), and evaluated for solubility, in-vitro release, and oral bioavailability of ibuprofen in rats. Loss of individual surface properties during melting and solidification as revealed by SENT micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C-max, and a significant decrease in T-max over pure ibuprofen. Preliminary results of this study suggested that the preparation of ibuprofen SDs using PEG 8000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution and bioavailability of ibuprofen.en_US
dc.language.isoen_USen_US
dc.publisherPHARMACEUTICAL SOC JAPANen_US
dc.subjectibuprofenen_US
dc.subjectsolid dispersionen_US
dc.subjectpolyethylene glycol 8000en_US
dc.subjectsolubilityen_US
dc.subjectdissolutionen_US
dc.subjectbioavailabilityen_US
dc.titleEnhancement of solubility, dissolution and Bioavailability of ibuprofen in solid dispersion systemsen_US
dc.typeArticleen_US
dc.relation.volume56-
dc.identifier.doi10.1248/cpb.56.569-
dc.relation.page569-574-
dc.relation.journalCHEMICAL & PHARMACEUTICAL BULLETIN-
dc.contributor.googleauthorNewa, Madhuri-
dc.contributor.googleauthorBhandari, Krishna Hari-
dc.contributor.googleauthorKim, Jong Oh-
dc.contributor.googleauthorIm, Jong Seob-
dc.contributor.googleauthorKim, Jung Ae-
dc.contributor.googleauthorYoo, Bong Kyu-
dc.contributor.googleauthorWoo, Jong Soo-
dc.contributor.googleauthorChoi, Han Gon-
dc.contributor.googleauthorYong, Chul Soon-
dc.relation.code2008201790-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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