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Enhancement of solubility, dissolution and Bioavailability of ibuprofen in solid dispersion systems

Title
Enhancement of solubility, dissolution and Bioavailability of ibuprofen in solid dispersion systems
Author
최한곤
Keywords
ibuprofen; solid dispersion; polyethylene glycol 8000; solubility; dissolution; bioavailability
Issue Date
2008-04
Publisher
PHARMACEUTICAL SOC JAPAN
Citation
CHEMICAL & PHARMACEUTICAL BULLETIN, v. 56, No. 4, Page. 569-574
Abstract
To improve its solubility, dissolution, and bioavailability; Ibuprofen-polyethylene glycol 8000 (PEG 8000) solid dispersions (SDs) with different drug loadings were prepared, characterized by scanning electron microscopy (SEM) and differential scanning calorimetry(DSC), and evaluated for solubility, in-vitro release, and oral bioavailability of ibuprofen in rats. Loss of individual surface properties during melting and solidification as revealed by SENT micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C-max, and a significant decrease in T-max over pure ibuprofen. Preliminary results of this study suggested that the preparation of ibuprofen SDs using PEG 8000 as a meltable hydrophilic polymer carrier could be a promising approach to improve solubility, dissolution and bioavailability of ibuprofen.
URI
https://www.jstage.jst.go.jp/article/cpb/56/4/56_4_569/_article/-char/ja/http://repository.hanyang.ac.kr/handle/20.500.11754/104468
ISSN
0009-2363
DOI
10.1248/cpb.56.569
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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