12 0

Self-Assembling Peptide Amphiphile-Based Nanofiber Gel for Bioresponsive Cisplatin Delivery

Title
Self-Assembling Peptide Amphiphile-Based Nanofiber Gel for Bioresponsive Cisplatin Delivery
Author
김진기
Keywords
Cisplatin; matrix metalloproteinase-2; nanofiber; peptide amphiphile; targeted drug delivery; MESENCHYMAL STEM-CELLS; HYBRID SCAFFOLD; DIFFERENTIATION; THERAPEUTICS; STRATEGIES; NETWORKS; MATRICES; THERAPY; COMPLEX; CANCER
Issue Date
2009-05
Publisher
AMER CHEMICAL SOC
Citation
MOLECULAR PHARMACEUTICS, v. 6, No. 3, Page. 978-985
Abstract
The aim of this study is to develop a bioresponsive cisplatin (CDDP) delivery system with a self-assembling peptide amphiphile (PA) comprising a cell-adhesive matrix metalloproteinase-2 (MMP-2)-sensitive GTAGLIGQRGDS and a fatty acid. A biomimetic CDDP-PA gel was spontaneously formed upon incubating a mixture of CDDP and the PA for 5 h at 37 degrees C. CDDP-PA gel formation was confirmed by rheological analysis. The structure of self-assembled CDDP-PA nanofibers inside the gel was determined by transmission electron microscopy (TEM). Bioresponsive drug release from the biomimetic gel was demonstrated by in vitro MMP-2-triggered CDDP release. The MMP-2-sensitive CDDP release was dependent on the enzyme concentration in the medium. Enzymatic degradation of the CDDP-PA gel was confirmed by TEM images of the gel degraded in an MMP-2 containing medium. The MMP-2-triggered CDDP release as well as the presentation of RGDS in the gel would potentially provide a spatially and temporally controlled delivery system for targeted anticancer drug delivery.
URI
https://pubs.acs.org/doi/abs/10.1021/mp900009nhttp://repository.hanyang.ac.kr/handle/20.500.11754/103971
ISSN
1543-8384
DOI
10.1021/mp900009n
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE