Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김철영 | - |
dc.date.accessioned | 2019-05-10T04:50:55Z | - |
dc.date.available | 2019-05-10T04:50:55Z | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | Natural Product Sciences, v. 23, No. 4, Page. 247-252 | en_US |
dc.identifier.issn | 1226-3907 | - |
dc.identifier.issn | 2288-9027 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.20307/nps.2017.23.4.247 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/103805 | - |
dc.description.abstract | The methylglyoxal (MGO) trapping constituents from onion (Allium cepa L.) peels were investigated using pre-column incubation of MGO and crude extract followed by HPLC analysis. The peak areas of MGO trapping compounds decreased, and their chemical structures were identified by HPLC-ESI/MS. Among major constituents in outer scale of onion, 2-(3,4-dihydroxybenzoyl)-2,4,6-trihydroxy-3(2H)-benzofuranone (2) was more effective MGO scavenger than quercetin (6) and its 4′-glucoside, spiraeoside (3). After 1 h incubation, compound 2 trapped over 90% MGO at a concentration of 0.5 mM under physiological conditions, but compounds 3 and 6 scavenged 45%, 16% MGO, respectively. HPLC-ESI/MS showed that compound 2 trapped two molecules of MGO to form a di-MGO adduct and compounds 3 and 6 captured one molecule of MGO to form mono-MGO adducts, and the positions 6 and 8 of the A ring of flavonoids were major active sites for trapping MGO. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korean Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI14C0018). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Korean Society of Pharmacognosy | en_US |
dc.subject | Allium cepa L. | en_US |
dc.subject | Methylglyoxal trapping | en_US |
dc.subject | Pre-column incubation | en_US |
dc.subject | Flavonoids | en_US |
dc.title | Rapid identification of methylglyoxal trapping constituents from onion peels by pre-column incubation method | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 23 | - |
dc.identifier.doi | 10.20307/nps.2017.23.4.247 | - |
dc.relation.page | 247-252 | - |
dc.relation.journal | Natural Product Sciences | - |
dc.contributor.googleauthor | Kim, Ji Hoon | - |
dc.contributor.googleauthor | Kim, Myeong Il | - |
dc.contributor.googleauthor | Syed, Ahmed Shah | - |
dc.contributor.googleauthor | Jung, Kiwon | - |
dc.contributor.googleauthor | Kim, Chul Young | - |
dc.relation.code | 2017036111 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | chulykim | - |
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