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Fluorescence tunable thiophene-bis(benzimidazole)-based probes for a cascade trace detection of Hg2+ and lysine: A molecular switch mimic

Title
Fluorescence tunable thiophene-bis(benzimidazole)-based probes for a cascade trace detection of Hg2+ and lysine: A molecular switch mimic
Author
채필석
Keywords
Thiophene-bis(benzimidazole); Hg2+; Lysine; ON-OFF-ON; Switch; Logic gate
Issue Date
2019-02
Publisher
ELSEVIER SCIENCE SA
Citation
SENSORS AND ACTUATORS B-CHEMICAL, v. 281, Page. 933-944
Abstract
Six thiophene-bis(benzimidazole)-based molecular probes with tunable fluorescence emission were synthesized for selective Hg2+ detection. Probe 1 contains a thiophene-bis(benzimidazole) unit without an appendage, while probes 2-4 have multiple appendages on benzimidazole rings of the core and probe 6/7 has two biphenyl appendages on the thiophene ring. Fluorescence emissions of all these probes were selectively quenched upon Hg2+ addition, but probe 7 provided the most sensitive detection of Hg2+, giving the highest association constant (K-a (7) = 2.38 x 10(6) M-1) and the lowest observed and calculated limit of detections (LODs) (5 nM and 0.047 pM, respectively). Thus, the probe 7-Hg2+ complex was further tested for detection of a biomolecule as a next step. Among the various biomolecules tested (including amino acids), L-lysine (Lys) uniquely showed a full restoration of the fluorescence intensity of [probe 7 + Hg2+ (1:2)]-complex to the level of the free probe, with an LOD of 5 nM. Thus, a cascade detection of Hg2+ and Lys was attained by probe 7 via selective quenching and recovering of the fluorescence intensity, which enables us to build an "ON-OFF-ON" switch and logic gate at a molecular level. The current system was fully studied by various analytical methods such as UV-vis, fluorescence, and H-1 NMR spectroscopies, IR, FE-SEM images, and DFT calculations.
URI
https://www.sciencedirect.com/science/article/pii/S0925400518319774?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/103684
ISSN
0925-4005
DOI
10.1016/j.snb.2018.11.023
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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