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High Ki67/BCL2 index is associated with worse outcome in early-stage breast cancer.

Title
High Ki67/BCL2 index is associated with worse outcome in early-stage breast cancer.
Author
민경환
Keywords
PROGRAMMED CELL-DEATH; BCL-2 EXPRESSION; GUIDELINE RECOMMENDATIONS; PROGNOSTIC-SIGNIFICANCE; PRIMARY CHEMOTHERAPY; ESTROGEN-RECEPTORS; AMERICAN SOCIETY; PATIENT SURVIVAL; GRADING SYSTEM; P53 EXPRESSION
Issue Date
2016-12
Publisher
BMJ PUBLISHING GROUP
Citation
POSTGRADUATE MEDICAL JOURNAL, v. 92, NO 1094, Page. 707-714
Abstract
Aims Breast cancers are heterogeneous, making it essential to recognise several biomarkers for cancer outcome predictions. Ki67 proliferation index and B cell lymphoma 2 (BCL2) proteins are widely used as prognostic indicators in many types of malignancies. While Ki67 is a marker of normal or tumour cell proliferation, BCL2 plays a central role in antiproliferative activities. A combination of these two biomarkers with contrary purposes can provide enhanced prognostic accuracy than an analysis using a single biomarker. Methods We evaluated Ki67 and BCL2 expression with 203 cases of breast cancer. The relative expression of each biomarker named as Ki67/BCL2 index was divided into two groups (low vs high) with the use of area under receiver operating characteristic curves. Results There were significant correlations between Ki67/BCL2 index and clinicopathological findings such as age, tumour stage, size and necrosis, histological grade, extensive intraductal component, lymphatic and vascular invasion, oestrogen receptor, progesterone receptor, human epithelial growth factor receptor 2 and p53 expression (all p<0.05). In univariate and multivariate analyses, high Ki67/BCL2 index correlated with shorter disease-free survival and overall survival in patients with early stage invasive ductal carcinoma (all p< 0.05). Conclusions The Ki67/BCL2 index should be considered as a prognostic predictor in patients with early stage invasive ductal carcinoma.
URI
https://pmj.bmj.com/content/92/1094/707http://repository.hanyang.ac.kr/handle/20.500.11754/103514
ISSN
0032-5473; 1469-0756
DOI
10.1136/postgradmedj-2015-133531
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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