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Host Cell Nuclear Localization of Shigella flexneri Effector OspF Is Facilitated by SUMOylation

Title
Host Cell Nuclear Localization of Shigella flexneri Effector OspF Is Facilitated by SUMOylation
Author
김동욱
Keywords
Shigella flexneri; effector; OspF; SUMO; nuclear localization; SECRETION SYSTEM EFFECTORS; PHOSPHOTHREONINE LYASE; III SECRETION; SALMONELLA EFFECTOR; IMMUNE-RESPONSES; PROTEIN; PATHOGENS; UBIQUITIN; TARGETS; INVASION
Issue Date
2017-03
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 27, No. 3, Page. 610-615
Abstract
When Shigella infect host cells, various effecter molecules are delivered into the cytoplasm of the host cell through the type III secretion system (TTSS) to facilitate their invasion process and control the host immune responses. Among these effectors, the S. flexneri effector OspF dephosphorylates mitogen- activated protein kinases and translocates itself to the nucleus, thus preventing histone H3 modification to regulate expression of proinflammatory cytokines. Despite the critical role of OspF, the mechanism by which it localizes in the nucleus has remained to be elucidated. In the present study, we identified a potential small ubiquitinrelated modifier (SUMO) modification site within OspF and we demonstrated that Shigella TTSS effector OspF is conjugated with SUMO in the host cell and this modification mediates the nuclear translocation of OspF. Our results show a bacterial virulence factor can exploit host post-translational machinery to execute its intracellular trafficking.
URI
http://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1611.11066http://repository.hanyang.ac.kr/handle/20.500.11754/103173
ISSN
1017-7825; 1738-8872
DOI
10.4014/jmb.1611.11066
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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