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Cell-Free Hydrogel System Based on a Tissue-Specific Extracellular Matrix for In Situ Adipose Tissue Regeneration

Title
Cell-Free Hydrogel System Based on a Tissue-Specific Extracellular Matrix for In Situ Adipose Tissue Regeneration
Author
조용우
Keywords
adipose-derived soluble extracellular matrix; cell-free scaffold system; host cell recruitment; in situ adipose tissue regeneration; thermosensitive extracellular matrix hydrogel; MESENCHYMAL STEM-CELLS; PROGENITOR CELLS; GROWTH-FACTOR; FAT PAD; STIFFNESS; ADIPOGENESIS; SCAFFOLDS; DELIVERY; OBESITY; REPAIR
Issue Date
2017-02
Publisher
AMER CHEMICAL SOC
Citation
ACS APPLIED MATERIALS & INTERFACES, v. 9, No. 10, Page. 8581-8588
Abstract
Well-designed scaffolds provide appropriate niches that can effectively recruit host cells and induce differentiation of recruited cells into the desired cell types, facilitating in situ tissue regeneration. Here we report a tissue-specific extracellular matrix (ECM) hydrogel composed of adipose-derived soluble ECM (sECM) and methylcellulose (MC) as a cell-free scaffold system for adipose tissue regeneration. The sECM MC hydrogels showed a thermosensitive sol-gel phase transition and rapidly formed a soft hydrogel with a stiffness of 3.8 kPa at body temperature. An in vivo study showed that the sECM MC hydrogel facilitated the infiltration of host cell populations, particularly adipose-derived stem cells (ASCs) and adipose tissue macrophages (ATMs) that directly contribute to the adipose tissue regeneration. Moreover, the hydrogel significantly enhanced host-derived adipogenesis and angiogenesis without exogenous cells or bioactive molecules. Our results indicate that the sECM MC hydrogels provide mechanical and biochemical cues for host-derived adipose regeneration. Overall, the sECM MC hydrogels are a highly promising cell-free therapeutic approach for in situ adipose tissue regeneration.
URI
https://pubs.acs.org/doi/abs/10.1021/acsami.6b16783http://repository.hanyang.ac.kr/handle/20.500.11754/103142
ISSN
1944-8244
DOI
10.1021/acsami.6b16783
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MATERIALS SCIENCE AND CHEMICAL ENGINEERING(재료화학공학과) > Articles
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