166 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author김철영-
dc.date.accessioned2019-04-30T08:00:57Z-
dc.date.available2019-04-30T08:00:57Z-
dc.date.issued2017-01-
dc.identifier.citationJOURNAL OF SEXUAL MEDICINE, v. 14, No. 1, Page. 59-68en_US
dc.identifier.issn1743-6095-
dc.identifier.issn1743-6109-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1743609516308335-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/103119-
dc.description.abstractIntroduction: The development of novel therapeutic options is imperative in patients with erectile dysfunction, especially those non-responsive to phosphodiesterase type 5 inhibitors. LDD175, a potent BKCa channel opener, has a relaxation effect on the in vitro cavernosal smooth muscle strip. Aim: To investigate the effect of LDD175 on erectile function using in vivo animal disease model. Methods: Male Sprague-Dawley rats were assigned to a normal control group and seven diabetic groups: diabetic control, sildenafil (1 and 5 mg/kg), LDD175 (5 and 10 mg/kg), LDD175 5 mg/kg plus sildenafil 1 mg/kg, and LDD175 10 mg/kg plus tetraethylammonium. Main Outcome Measures: Intracavernosal pressure (ICP), ratio of ICP to mean arterial pressure (MAP), and the area under curve of ICP/MAP of eight groups were compared using in vivo pelvic nerve stimulation. Results: The ICP, ICP/MAP ratio, and area under curve of the ICP/MAP ratio of the normal control rats increased with an increase in electrical field stimulation voltage. All parameters in the diabetic control group were significantly lower than those in the normal control rats, with an electrical field stimulation ranging from 1 to 5 V (P ˂.05). LDD175 improved the erectile response in diabetic rats in a dose-dependent manner. The combination of sildenafil (1 mg/kg) and LDD175 (5 mg/kg) showed a significant additive effect (P ˂.05) on the improvement of erectile function compared with sildenafil (1 mg/kg) alone. The enhancement of erectile function by LDD175 was completely blocked by tetraethylammonium. Conclusion: The results showed that the BKCa channel opener LDD175 improved erectile function in an in vivo diabetic rat model. Furthermore, combination therapy of LDD175 and sildenafil had an additive effect on the improvement of erectile function in diabetic rats. LDD175 could be a new candidate for the treatment of erectile dysfunction. Copyright (C) 2016, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipThis research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute funded by the Ministry of Health & Welfare, Republic of Korea (HI14C0018).en_US
dc.language.isoen_USen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subjectErectile Dysfunctionen_US
dc.subjectBK Channelen_US
dc.subjectLDD175en_US
dc.subjectPhosphodiesterase Type 5en_US
dc.subjectACTIVATED POTASSIUM CHANNELSen_US
dc.subjectSMOOTH-MUSCLE-CELLSen_US
dc.subjectLARGE-CONDUCTANCEen_US
dc.subjectDYSFUNCTIONen_US
dc.subjectPHARMACOTHERAPYen_US
dc.subjectEFFICACYen_US
dc.subjectTHERAPYen_US
dc.subjectGENEen_US
dc.titleEffect of BKCa Channel Opener LDD175 on Erectile Function in an In Vivo Diabetic Rat Modelen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume14-
dc.identifier.doi10.1016/j.jsxm.2016.11.316-
dc.relation.page59-68-
dc.relation.journalJOURNAL OF SEXUAL MEDICINE-
dc.contributor.googleauthorSung, Hyun Hwan-
dc.contributor.googleauthorKang, Su Jeong-
dc.contributor.googleauthorChae, Mee Ree-
dc.contributor.googleauthorKim, Hye Kyung-
dc.contributor.googleauthorPark, Jong Kwan-
dc.contributor.googleauthorKim, Chul Young-
dc.contributor.googleauthorLee, Sung Won-
dc.relation.code2017009324-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidchulykim-
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE