138 0

Efficacy of the HLA-B*58:01 Screening Test in Preventing Allopurinol-Induced Severe Cutaneous Adverse Reactions in Patients with Chronic Renal Insufficiency - A Prospective Study

Title
Efficacy of the HLA-B*58:01 Screening Test in Preventing Allopurinol-Induced Severe Cutaneous Adverse Reactions in Patients with Chronic Renal Insufficiency - A Prospective Study
Author
김근호
Keywords
Allopurinol; HLA-B*58:01 allele; Drug hypersensitivity; Renal insufficiency; Chronic
Issue Date
2019-01
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, v. 7, Page. 1271-1276
Abstract
Background Thus far, human leukocyte antigen (HLA)-B ∗ 58:01 has been recognized as the most important risk factor for allopurinol induced severe cutaneous adverse reactions (SCARs). Objective To determine the usefulness of prospective screening for the HLA-B ∗ 58:01 allele to identify Korean individuals at risk for SCARs induced by allopurinol treatment. Methods We prospectively enrolled 542 patients with chronic renal insufficiency (CRI) from 10 hospitals nationwide and performed DNA genotyping to determine whether they carried the HLA-B ∗ 58:01 allele. Of these, 503 HLA-B ∗ 58:01-negative patients (92.8% of total) were treated with allopurinol, and 39 HLA-B ∗ 58:01-positive patients (7.2%) were treated with febuxostat, an alternative drug. The patients then were followed up biweekly for 90 days using a telephone survey to monitor symptoms of adverse drug reactions, including SCARs. As a control, we used the historical incidence rate of allopurinol-induced SCARs in 4002 patients with CRI from the same hospitals who were enrolled retrospectively. Results Nineteen patients in the prospective cohort developed mild and transient adverse reactions but none showed allopurinol-induced SCARs. By contrast, we identified 38 patients with allopurinol-induced SCARs (0.95%) in the historical control. The difference in the incidence of allopurinol-induced SCARs between the prospective cohort and historical control was statistically significant (0% vs 0.95%, respectively; P = .029). Conclusions The present study demonstrated the clinical usefulness of the HLA-B ∗ 58:01 screening test before allopurinol administration to prevent allopurinol-induced SCARs in patients with CRI.
URI
https://www.sciencedirect.com/science/article/pii/S2213219818308341http://repository.hanyang.ac.kr/handle/20.500.11754/102999
ISSN
2213-2198; 2213-2201
DOI
10.1016/j.jaip.2018.12.012
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE