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dc.contributor.author강용한-
dc.date.accessioned2019-04-29T23:49:53Z-
dc.date.available2019-04-29T23:49:53Z-
dc.date.issued2016-11-
dc.identifier.citationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v. 37, No. 11, Page. 1754-1759en_US
dc.identifier.issn0253-2964-
dc.identifier.issn1229-5949-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/bkcs.10962-
dc.identifier.urihttps://repository.hanyang.ac.kr/handle/20.500.11754/102961-
dc.description.abstractThis research focused on the method of using dimeric phosphoramidite blocks to synthesize oligonucleotides for development as oligonucleotide drugs. A 16-mer oligonucleotide with the randomly selected sequence of C*C*T*C*G*C*T*C*T*C*G*C*C*C*G*C was synthesized using CC, GC, and TC dimers, a combination of monomers and dimers, or only monomers as building blocks. Using dimer blocks in this synthetic method provided a significant decrease in critical impurities that had similar properties to the main product, which was confirmed by LC-MS and HPLC analysis.en_US
dc.language.isoen_USen_US
dc.publisherWILEY-V C H VERLAG GMBHen_US
dc.subjectPhosphoramiditeen_US
dc.subject2-O-Methoxyethyl oligonucleotideen_US
dc.subjectSolid-phase synthesisen_US
dc.subjectDimer phosphoramidite blocken_US
dc.titleSolid-Phase Synthesis of 2-O-Methoxyethyl Oligonucleotides Using Dimeric Phosphoramidite Blocksen_US
dc.typeArticleen_US
dc.relation.no11-
dc.relation.volume37-
dc.identifier.doi10.1002/bkcs.10962-
dc.relation.page1754-1759-
dc.relation.journalBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.contributor.googleauthorYu, Gi Weon-
dc.contributor.googleauthorKang, Yong Han-
dc.relation.code2016002474-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E]-
dc.sector.departmentDEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING-
dc.identifier.pidyhmkang-


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