Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강용한 | - |
dc.date.accessioned | 2019-04-29T23:49:53Z | - |
dc.date.available | 2019-04-29T23:49:53Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v. 37, No. 11, Page. 1754-1759 | en_US |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/full/10.1002/bkcs.10962 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/102961 | - |
dc.description.abstract | This research focused on the method of using dimeric phosphoramidite blocks to synthesize oligonucleotides for development as oligonucleotide drugs. A 16-mer oligonucleotide with the randomly selected sequence of C*C*T*C*G*C*T*C*T*C*G*C*C*C*G*C was synthesized using CC, GC, and TC dimers, a combination of monomers and dimers, or only monomers as building blocks. Using dimer blocks in this synthetic method provided a significant decrease in critical impurities that had similar properties to the main product, which was confirmed by LC-MS and HPLC analysis. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | WILEY-V C H VERLAG GMBH | en_US |
dc.subject | Phosphoramidite | en_US |
dc.subject | 2-O-Methoxyethyl oligonucleotide | en_US |
dc.subject | Solid-phase synthesis | en_US |
dc.subject | Dimer phosphoramidite block | en_US |
dc.title | Solid-Phase Synthesis of 2-O-Methoxyethyl Oligonucleotides Using Dimeric Phosphoramidite Blocks | en_US |
dc.type | Article | en_US |
dc.relation.no | 11 | - |
dc.relation.volume | 37 | - |
dc.identifier.doi | 10.1002/bkcs.10962 | - |
dc.relation.page | 1754-1759 | - |
dc.relation.journal | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.contributor.googleauthor | Yu, Gi Weon | - |
dc.contributor.googleauthor | Kang, Yong Han | - |
dc.relation.code | 2016002474 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING | - |
dc.identifier.pid | yhmkang | - |
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