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LONG-TERM EXPOSURE TO TRIPHENYLPHOSPHATE ALTERS HORMONE BALANCE AND HPG, HPI, AND HPT GENE EXPRESSION IN ZEBRAFISH (DANIO RERIO)

Title
LONG-TERM EXPOSURE TO TRIPHENYLPHOSPHATE ALTERS HORMONE BALANCE AND HPG, HPI, AND HPT GENE EXPRESSION IN ZEBRAFISH (DANIO RERIO)
Author
문효방
Keywords
Flame retardants; Organophosphates; Endocrine disruptors; Sex hormone; Thyroid hormone
Issue Date
2016-09
Publisher
WILEY-BLACKWELL
Citation
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, v. 35, No. 9, Page. 2288-2296
Abstract
With the global decline in the use of polybrominated diphenyl ethers, the demand for alternative flame retardants, such as triphenylphosphate (TPP), has increased substantially. Triphenylphosphate is now detected in various environments including aquatic ecosystems worldwide. However, studies on the toxicological consequences of chronic TPP exposure on aquatic organisms are scarce. The zebrafish model was used to investigate the effects of long-term TPP exposure on the endocrine system. Zebrafish embryos were exposed to 5 mu g/L, 50 mu g/L, or 500 mu g/L TPP for 120 d, and hormonal and transcriptional responses were measured along the hypothalamic-pituitary-gonad (HPG) axis, the hypothalamic-pituitary-interrenal (HPI) axis, and the hypothalamic-pituitary-thyroid (HPT) axis. Exposure to TPP significantly increased plasma 17 beta-estradiol, but decreased 11-ketotestosterone in both sexes. Gene expression data support these changes. In the HPI axis, plasma cortisol and proopiomelanocortin (pomc) and mineralocorticoid receptor transcripts increased in females, but in males cortisol decreased whereas pomc increased (p˂0.05). Thyroxine and triiodothyronine increased, and thyrotrophin-releasing hormone receptor 2 (trhr2) and trh expression were affected only in females (p˂0.05). In summary, long-term exposure to TPP enhanced estrogenicity in both males and females, potentially through influencing the HPG axis, but modulated the HPI, and HPT axes differently by sex, suggesting that both genomic and nongenomic responses might be involved. (C) 2016 SETAC
URI
https://setac.onlinelibrary.wiley.com/doi/full/10.1002/etc.3395https://repository.hanyang.ac.kr/handle/20.500.11754/102738
ISSN
0730-7268; 1552-8618
DOI
10.1002/etc.3395
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MARINE SCIENCE AND CONVERGENCE ENGINEERING(해양융합공학과) > Articles
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