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Effect of Polylysine on Scrapie Prion Protein Propagation in Spleen during Asymptomatic Stage of Experimental Prion Disease in Mice

Title
Effect of Polylysine on Scrapie Prion Protein Propagation in Spleen during Asymptomatic Stage of Experimental Prion Disease in Mice
Author
류종석
Keywords
Prion; PrPSc; animal model; spleen; brain; polylysine
Issue Date
2016-09
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 26, No. 9, Page. 1657-1660
Abstract
Prion diseases are incurable neurodegenerative disorders. Our previous study demonstrated that polylysine was effective in prolonging the incubation period in a rodent model and in alleviating the scrapie prion protein (PrPSc) burden in the brain at the terminal stage of the disease. Here, we report that intraperitoneal administration of polylysine suppresses the accumulation of prions in the spleen during the early stages of the disease. This study supports the congruence of PrPSc inhibition by polylysine in both the spleen and brain.
URI
http://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1601.01057http://repository.hanyang.ac.kr/handle/20.500.11754/102713
ISSN
1017-7825; 1738-8872
DOI
10.4014/jmb.1601.01057
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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