Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김진기 | - |
dc.date.accessioned | 2019-04-24T01:43:55Z | - |
dc.date.available | 2019-04-24T01:43:55Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 11, Page. 3813-3824 | en_US |
dc.identifier.issn | 1178-2013 | - |
dc.identifier.uri | https://www.dovepress.com/improved-skin-permeation-of-methotrexate-via-nanosized-ultradeformable-peer-reviewed-article-IJN | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/102669 | - |
dc.description.abstract | The aim of this study is to investigate methotrexate-entrapped ultradeformable liposomes (MTX-UDLs) for potential transdermal application. MTX-UDLs were prepared by extrusion method with phosphatidylcholine as a bilayer matrix and sodium cholate or Tween 80 as an edge activator. The physicochemical properties of MTX-UDLs were determined in terms of particle size, polydispersity index, zeta potential, and entrapment efficiency. The deformability of MTX-UDLs was compared with that of methotrexate-entrapped conventional liposomes (MTX-CLs) using a steel pressure filter device. The skin permeation of MTX-UDLs was investigated using Franz diffusion cell, and the skin penetration depth of rhodamine 6G-entrapped UDLs was determined by confocal laser scanning microscopy. MTX-UDLs showed a narrow size distribution, with the particle size of similar to 100 nm. The deformability of MTX-UDLs was two to five times greater than that of MTX-CLs. The skin permeation of MTX-UDLs was significantly improved compared with MTX-CLs and free MTX solution. The optimized UDLs (phosphatidylcholine: Tween 80 = 7:3, w/w) showed a higher fluorescence intensity than conventional liposomes at every increment of skin depth. Thus, the optimized UDLs could be promising nanocarriers for systemic delivery of MTX across skin. | en_US |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2013R1A1A1010181). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | DOVE MEDICAL PRESS LTD | en_US |
dc.subject | ultradeformable liposomes | en_US |
dc.subject | deformability | en_US |
dc.subject | methotrexate | en_US |
dc.subject | skin permeation | en_US |
dc.subject | transdermal delivery | en_US |
dc.subject | ENHANCED TRANSDERMAL DELIVERY | en_US |
dc.subject | IN-VIVO EVALUATION | en_US |
dc.subject | LIPID VESICLES | en_US |
dc.subject | DRUG CARRIERS | en_US |
dc.subject | STRATUM-CORNEUM | en_US |
dc.subject | PHYSICOCHEMICAL CHARACTERIZATION | en_US |
dc.subject | DEFORMABLE LIPOSOMES | en_US |
dc.subject | ETHANOLIC LIPOSOMES | en_US |
dc.subject | VESICULAR CARRIER | en_US |
dc.subject | EDGE ACTIVATORS | en_US |
dc.title | Improved skin permeation of methotrexate via nanosized ultradeformable liposomes | en_US |
dc.type | Article | en_US |
dc.relation.volume | 11 | - |
dc.identifier.doi | 10.2147/IJN.S109565 | - |
dc.relation.page | 3813-3824 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF NANOMEDICINE | - |
dc.contributor.googleauthor | Zeb, A | - |
dc.contributor.googleauthor | Qureshi, OS | - |
dc.contributor.googleauthor | Kim, HS | - |
dc.contributor.googleauthor | Cha, J.H | - |
dc.contributor.googleauthor | Kim, HS | - |
dc.contributor.googleauthor | Kim, JK | - |
dc.relation.code | 2016000827 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | jinkikim | - |
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