21 0

Improved skin permeation of methotrexate via nanosized ultradeformable liposomes

Title
Improved skin permeation of methotrexate via nanosized ultradeformable liposomes
Author
김진기
Keywords
ultradeformable liposomes; deformability; methotrexate; skin permeation; transdermal delivery; ENHANCED TRANSDERMAL DELIVERY; IN-VIVO EVALUATION; LIPID VESICLES; DRUG CARRIERS; STRATUM-CORNEUM; PHYSICOCHEMICAL CHARACTERIZATION; DEFORMABLE LIPOSOMES; ETHANOLIC LIPOSOMES; VESICULAR CARRIER; EDGE ACTIVATORS
Issue Date
2016-08
Publisher
DOVE MEDICAL PRESS LTD
Citation
INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 11, Page. 3813-3824
Abstract
The aim of this study is to investigate methotrexate-entrapped ultradeformable liposomes (MTX-UDLs) for potential transdermal application. MTX-UDLs were prepared by extrusion method with phosphatidylcholine as a bilayer matrix and sodium cholate or Tween 80 as an edge activator. The physicochemical properties of MTX-UDLs were determined in terms of particle size, polydispersity index, zeta potential, and entrapment efficiency. The deformability of MTX-UDLs was compared with that of methotrexate-entrapped conventional liposomes (MTX-CLs) using a steel pressure filter device. The skin permeation of MTX-UDLs was investigated using Franz diffusion cell, and the skin penetration depth of rhodamine 6G-entrapped UDLs was determined by confocal laser scanning microscopy. MTX-UDLs showed a narrow size distribution, with the particle size of similar to 100 nm. The deformability of MTX-UDLs was two to five times greater than that of MTX-CLs. The skin permeation of MTX-UDLs was significantly improved compared with MTX-CLs and free MTX solution. The optimized UDLs (phosphatidylcholine: Tween 80 = 7:3, w/w) showed a higher fluorescence intensity than conventional liposomes at every increment of skin depth. Thus, the optimized UDLs could be promising nanocarriers for systemic delivery of MTX across skin.
URI
https://www.dovepress.com/improved-skin-permeation-of-methotrexate-via-nanosized-ultradeformable-peer-reviewed-article-IJNhttp://repository.hanyang.ac.kr/handle/20.500.11754/102669
ISSN
1178-2013
DOI
10.2147/IJN.S109565
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE