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Sequence Variations in the Non-Coding Sequence of CTX Phages in Vibrio cholerae

Title
Sequence Variations in the Non-Coding Sequence of CTX Phages in Vibrio cholerae
Author
김동욱
Keywords
V. cholerae; CTX phage; non-coding sequence; PHI; PROPHAGE; INTEGRATION; STRAINS; GENOME; O1; MOZAMBIQUE; DIVERSITY; ELEMENTS; HYBRID
Issue Date
2016-08
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 26, No. 8, Page. 1473-1480
Abstract
This study focused on the variations in the non-coding sequences between ctxB and rstR of various CTX phages. The non-coding sequences of CTX-1 and CTX-cla are phage type-specific. The length of the non-coding region of CTX-1 and CTX-cla is 601 and 730 nucleotides, respectively. The non-coding sequence of CTX phage could be divided into three regions. There is a phage type-specific Variable region between two homologous Common regions (Common regions 1 and 2). The non-coding sequence of RS1 element is similar to CTX-1 except that Common region 1 is replaced by a short RS1-specific sequence. The non-coding sequences of CTX-2 and CTX-cla are homologous, indicating the non-coding sequence of CTX-2 is derived from CTX-cla. The non-coding region of CTX-O139 is similar to CTX-cla and CTX-2; however, it contains an extra phage type-specific sequence between Common region 2 and rstR. The variations in the non-coding sequences of CTX phages might be associated with the difference in the replication efficiency and the directionality in the integration into the V. cholerae chromosome.
URI
http://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1604.04022http://repository.hanyang.ac.kr/handle/20.500.11754/102640
ISSN
1017-7825; 1738-8872
DOI
10.4014/jmb.1604.04022
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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