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dc.contributor.author류종석-
dc.date.accessioned2019-04-22T07:39:18Z-
dc.date.available2019-04-22T07:39:18Z-
dc.date.issued2016-06-
dc.identifier.citationBIOMEDICAL CHROMATOGRAPHY, v. 30, No. 6, Page. 976-982en_US
dc.identifier.issn0269-3879-
dc.identifier.issn1099-0801-
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/bmc.3640-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/102487-
dc.description.abstractGastrodia rhizome, a dried and steamed tuber of Gastrodia elata Blume (Orchidaceae), has been traditionally used in Korea, China and Japan for the treatment of neurological and nervous disorders such as headaches, dizziness, vertigo and convulsive illnesses. The ethyl acetate and water extracts of G. elata stimulated plasmin activity. The active ethyl acetate fraction was subjected to centrifugal partition chromatography (CPC) with a two-phase solvent system, composed of n-hexane-ethyl acetate-methanol-water (3:7:4:6, v/v) followed by semi-preparative HPLC purification to separate active compounds and the water fraction was purified by Diaion HP-20 resin and semi-preparative HPLC. In ethyl acetate extract, 4-hydroxybenzyl alcohol (1), 4-hydroxybenzoic acid (2), 4-hydroxybenzaldehyde (3), 4-ethoxymethylphenol (4), 4,4-oxybis(methylene)diphenol (5) and 4,4-methylenediphenol (6) were obtained with high purities. Parishin (7) and parishin B (8) were isolated from water extract. Among isolated compounds, 4-hydroxybenzyl alcohol (1), 4-hydroxybenzaldehyde (3) and 4-ethoxymethylphenol (4) significantly stimulated plasmin activity. Copyright (c) 2015 John Wiley Sons, Ltd.en_US
dc.description.sponsorshipThis research was supported by the Basic Science Research Program through the National Research Foundation of Korea, which is funded by the Ministry of Education (NRF-2013R1A1A2007371).en_US
dc.language.isoen_USen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subjectcentrifugal partition chromatographyen_US
dc.subjectGastrodia elata Rhizomeen_US
dc.subjectplasmin activityen_US
dc.subjectphenolic derivativesen_US
dc.titlePreparative purification of plasmin activity stimulating phenolic derivatives from Gastrodia elata using centrifugal partition chromatographyen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume30-
dc.identifier.doi10.1002/bmc.3640-
dc.relation.page976-982-
dc.relation.journalBIOMEDICAL CHROMATOGRAPHY-
dc.contributor.googleauthorJeon, Je-Seung-
dc.contributor.googleauthorKim, Jeeyoung-
dc.contributor.googleauthorPark, Soyoung-
dc.contributor.googleauthorRyou, Chongsuk-
dc.contributor.googleauthorKim, Chul Young-
dc.relation.code2016000537-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidcryou2-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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