Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배옥남 | - |
dc.date.accessioned | 2019-04-22T06:21:18Z | - |
dc.date.available | 2019-04-22T06:21:18Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | BIOLOGICAL & PHARMACEUTICAL BULLETIN, v. 39, No. 5, Page. 728-736 | en_US |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | https://www.jstage.jst.go.jp/article/bpb/39/5/39_b15-00823/_article/-char/ja/ | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/102440 | - |
dc.description.abstract | Dendropanax morbifera LEVEILLE (DP) has been used in traditional Korean medicines to treat a variety of inflammatory diseases. Although the in vitro anti-inflammatory potential of this plant is understood, its in vivo efficacy and underlying molecular mechanism of anti-inflammatory effects are largely unknown. We elucidated the anti-inflammatory and analgesic activities and the underlying molecular mechanisms of DP using in vitro and in vivo models. Lipopolysaccharide (LPS)-stimulated murine macrophages were used to analyze the in vitro anti-inflammatory potential of DP extract and to elucidate the underlying mechanisms. In vivo animal models of phorbol 12-myristate 13-acetate (TPA)-induced ear edema and acetic acid-induced writhing response tests were used to analyze the in vivo anti-inflammatory effects and anti-nociceptive effects of DP extract, respectively. Methanolic extract of DP (DPME) significantly inhibited the release of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) in LPS-activated macrophages. Among the five sub-fractions, the chloroform fraction (DP-C) showed the most potent suppressive effects against pro-inflammatory mediators and cytokines in LPS-stimulated macrophages. These effects were attributed to inhibition of nuclear factor-kappa B (NF-kappa B) nuclear translocation and c-Jun N terminal kinase (JNK) 1/2 phosphorylation and to activation of NF-E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling. DP-C exhibited strong protective in vivo effects in TPA-induced ear edema mouse model and acetic acid-induced writhing response test. Our data suggest that DP-C has potent anti-inflammatory and analgesic activities and may be a promising treatment against a variety of inflammatory diseases. | en_US |
dc.description.sponsorship | This work was supported by a Grant from Hanyang University (201400000001165). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PHARMACEUTICAL SOC JAPAN | en_US |
dc.subject | Dendropanax morbifera (DP) | en_US |
dc.subject | anti-inflammatory | en_US |
dc.subject | nuclear factor-kappa B (NF-kappa B) | en_US |
dc.subject | mitogen activated protein kinase (MAPK) | en_US |
dc.subject | NF-E2-related factor 2 (Nrf2) | en_US |
dc.subject | heme oxygenase-1 (HO-1) | en_US |
dc.title | Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of Dendropanax morbifera Mediated by the Nrf2/HO-1 Pathway | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 39 | - |
dc.identifier.doi | 10.1248/bpb.b15-00823 | - |
dc.relation.page | 728-736 | - |
dc.relation.journal | BIOLOGICAL & PHARMACEUTICAL BULLETIN | - |
dc.contributor.googleauthor | Akram, Muhammad | - |
dc.contributor.googleauthor | Kim, Kyeong-A | - |
dc.contributor.googleauthor | Kim, Eun-Sun | - |
dc.contributor.googleauthor | Syed, Ahmed Shah | - |
dc.contributor.googleauthor | Kim, Chul Young | - |
dc.contributor.googleauthor | Lee, Jong Soo | - |
dc.contributor.googleauthor | Bae, Ok-Nam | - |
dc.relation.code | 2016002225 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | onbae | - |
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