Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강용한 | - |
dc.date.accessioned | 2019-04-19T08:04:34Z | - |
dc.date.available | 2019-04-19T08:04:34Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.citation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v. 37, No. 5, Page. 667-673 | en_US |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/full/10.1002/bkcs.10749 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/102364 | - |
dc.description.abstract | Four types of methoxyethyl (MOE) nucleoside phosphoramidites, which are categorized as second-generation building blocks of antisense oligonucleotide drugs, were synthesized. Also, three types of MOE nucleoside dimer phosphoramidites were synthesized to increase the efficiency and oligomer purity in solid phase synthesis. The block-like dimer phosphoramidites can prevent or minimize the formation of the (N-1) mer impurity, thereby affording the fabrication of pure oligonucleotides and reducing the synthesis time by performing coupling reactions in the order of 2+2+2. | en_US |
dc.description.sponsorship | This work was supported by the research fund of Hanyang University (HY-2014-G). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | WILEY-V C H VERLAG GMBH | en_US |
dc.subject | Phosphoramidite | en_US |
dc.subject | Oligonucleotide | en_US |
dc.subject | Solid phase synthesis | en_US |
dc.subject | Dimer | en_US |
dc.subject | DEOXYRIBOPOLYNUCLEOTIDES | en_US |
dc.subject | OLIGONUCLEOTIDES | en_US |
dc.subject | POLYNUCLEOTIDES | en_US |
dc.subject | CONDENSATION | en_US |
dc.subject | ACTIVATOR | en_US |
dc.title | Synthesis of Methoxyethyl Nucleoside Dimer Phosphoramidites | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 37 | - |
dc.identifier.doi | 10.1002/bkcs.10749 | - |
dc.relation.page | 667-673 | - |
dc.relation.journal | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.contributor.googleauthor | Yu, Gi Weon | - |
dc.contributor.googleauthor | Kang, Yong Han | - |
dc.relation.code | 2016002474 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF CHEMICAL AND MOLECULAR ENGINEERING | - |
dc.identifier.pid | yhmkang | - |
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