Synthesis of Methoxyethyl Nucleoside Dimer Phosphoramidites

Title
Synthesis of Methoxyethyl Nucleoside Dimer Phosphoramidites
Author
강용한
Keywords
Phosphoramidite; Oligonucleotide; Solid phase synthesis; Dimer; DEOXYRIBOPOLYNUCLEOTIDES; OLIGONUCLEOTIDES; POLYNUCLEOTIDES; CONDENSATION; ACTIVATOR
Issue Date
2016-05
Publisher
WILEY-V C H VERLAG GMBH
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v. 37, No. 5, Page. 667-673
Abstract
Four types of methoxyethyl (MOE) nucleoside phosphoramidites, which are categorized as second-generation building blocks of antisense oligonucleotide drugs, were synthesized. Also, three types of MOE nucleoside dimer phosphoramidites were synthesized to increase the efficiency and oligomer purity in solid phase synthesis. The block-like dimer phosphoramidites can prevent or minimize the formation of the (N-1) mer impurity, thereby affording the fabrication of pure oligonucleotides and reducing the synthesis time by performing coupling reactions in the order of 2+2+2.
URI
https://onlinelibrary.wiley.com/doi/full/10.1002/bkcs.10749http://repository.hanyang.ac.kr/handle/20.500.11754/102364
ISSN
0253-2964; 1229-5949
DOI
10.1002/bkcs.10749
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > CHEMICAL AND MOLECULAR ENGINEERING(화학분자공학과) > Articles
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