Natural, semisynthetic and synthetic tyrosinase inhibitors

Title
Natural, semisynthetic and synthetic tyrosinase inhibitors
Author
이상열
Keywords
Inhibitor; melanin; skin-whitening; tyrosinase
Issue Date
2016-02
Publisher
TAYLOR & FRANCIS LTD
Citation
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, v. 31, No. 1, Page. 1-13
Abstract
Tyrosinase plays a pivotal role in the synthesis of melanin pigment synthesis on skin utilizing tyrosine as a substrate. Melanin is responsible for the protection against harmful ultraviolet irradiation, which can cause significant pathological conditions, such as skin cancers. However, it can also create esthetic problems when accumulated as hyperpigmented spots. Various skin-whitening ingredients which inhibit tyrosinase activity have been identified. Some of them, especially ones with natural product origins, possess phenolic moiety and have been employed in cosmetic products. Semi-synthetic and synthetic inhibitors have also been developed under inspiration of the natural inhibitors yet some of which have no phenolic groups. In this review, tyrosinase inhibitors with natural, semi-synthetic and synthetic origins are listed up with their structures, activities and characteristics. Further, a recent report on the adverse effect of a natural melanin synthesis inhibitor which was included in skin-whitening cosmetics is also briefly discussed.
URI
https://www.tandfonline.com/doi/abs/10.3109/14756366.2015.1004058http://repository.hanyang.ac.kr/handle/20.500.11754/102120
ISSN
1475-6366; 1475-6374
DOI
10.3109/14756366.2015.1004058
Appears in Collections:
RESEARCH INSTITUTE[E](부설연구소) > INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY(약학기술연구소) > Articles
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