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Persistence with Antihypertensive Medications in Uncomplicated Treatment-Naive Patients: Effects of Initial Therapeutic Classes

Title
Persistence with Antihypertensive Medications in Uncomplicated Treatment-Naive Patients: Effects of Initial Therapeutic Classes
Author
이주연
Keywords
Uncomplicated Hypertension; Persistence; Adherence; Therapeutic Class; HYPERTENSIVE PATIENTS; FOLLOW-UP; BLOOD-PRESSURE; PRIMARY-CARE; DRUG-USE; ADHERENCE; DISCONTINUATION; RISK; METAANALYSIS; POPULATION
Issue Date
2015-12
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v. 30, No. 12, Page. 1800-1806
Abstract
We aimed to assess one-year persistence with antihypertensive therapy (AHT) among newly treated uncomplicated hypertensive patients in Korea and to evaluate the effect of initial therapeutic classes on persistence. We retrospectively analyzed a random sample of 20% of newly treated uncomplicated hypertensive patients (n = 45,787) in 2012 from the National Health Insurance claims database. This group was classified into six cohorts based on initial AHT class. We then measured treatment persistence, allowing a prescription gap of 60 days. Adherence to AHT was assessed with the medication possession ratio. Calcium channel blockers (CCB, 43.7%) and angiotensin receptor blockers (ARB, 40.3%) were most commonly prescribed as initial monotherapy. Overall, 62.1% and 42.0% were persistent with any AHT and initial class at one year, respectively, and 64.2% were adherent to antihypertensive treatment. Compared with ARBs, the risk of AHT discontinuation was significantly increased with initial use of thiazide diuretics (hazard ratio [HR], 3.16
URI
https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2015.30.12.1800http://repository.hanyang.ac.kr/handle/20.500.11754/102021
ISSN
1011-8934; 1598-6357
DOI
10.3346/jkms.2015.30.12.1800
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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