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Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells

Title
Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells
Author
최한곤
Keywords
docetaxel; polyaspartic acid; drug delivery systems; antitumor; pH-sensitive; SOLID LIPID NANOPARTICLES; POLYMER HYBRID NANOPARTICLES; ANTICANCER DRUG; CO-DELIVERY; IN-VITRO; CATIONIC NANOPARTICLES; ANTITUMOR EFFICACY; INHIBITOR P27; BREAST-CANCER; THERAPY
Issue Date
2015-09
Publisher
DOVE MEDICAL PRESS LTD
Citation
INTERNATIONAL JOURNAL OF NANOMEDICINE, v. 10, Page. 5249-5262
Abstract
The attachment of polyethylene glycol (PEG) increases the circulation time of drug-containing nanoparticles; however, this also negatively affects cellular uptake. To overcome this problem, unique lipid polymer hybrid (LPH) nanoparticles were developed with a pH-responsive PEG layer that detached prior to cell uptake. Docetaxel (DTX) was incorporated into the lipid core of the nanoparticles, which was then shielded with the pH-responsive block co-polymer polyethylene glycol-b-polyaspartic acid (PEG-b-PAsp) using a modified emulsion method. The optimized LPH nanoparticles were similar to 200 nm and had a narrow size distribution. Drug release from DTX-loaded LPH (DTX-LPH) nanoparticles was pH-sensitive, which is beneficial for tumor targeting. More importantly, DTX-LPH nanoparticles were able to effectively induce apoptosis in cancer cells. The negative surface charge and PEG shell of vehicle remarkably enhanced the blood circulation and physiological activity of DTX-LPH nanoparticles compared with that of free DTX. The nanoparticles were also found to reduce the size of tumors in tumor-bearing xenograft mice. The in vivo anticancer effect of DTX-LPH nanoparticles was further confirmed by the elevated levels of caspase-3 and poly ADP ribose polymerase found in the tumors after treatment. Thus, the results suggest that this novel LPH system could be an effective new treatment for cancer.
URI
https://www.dovepress.com/tumor-targeting-ph-sensitive-nanoparticles-for-docetaxel-delivery-to-d-peer-reviewed-article-IJNhttp://repository.hanyang.ac.kr/handle/20.500.11754/101691
ISSN
1178-2013
DOI
10.2147/IJN.S89584
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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