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Whole-genome sequence comparisons reveal the evolution of Vibrio cholerae O1

Title
Whole-genome sequence comparisons reveal the evolution of Vibrio cholerae O1
Author
김동욱
Keywords
Vibrio cholerae; cholera; cholera toxin; phage CTX; EL-TOR STRAINS; CLASSICAL CTX PROPHAGE; TANDEM-REPEAT ANALYSIS; TOXIN-B; VARIANT; BIOTYPE; BANGLADESH; EMERGENCE; OUTBREAK; INDIA
Issue Date
2015-08
Publisher
ELSEVIER SCI LTD
Citation
TRENDS IN MICROBIOLOGY, v. 23, No. 8, Page. 479-489
Abstract
The analysis of the whole-genome sequences of Vibrio cholerae strains from previous and current cholera pandemics has demonstrated that genomic changes and alterations in phage CTX (particularly in the gene encoding the B subunit of cholera toxin) were major features in the evolution of V. cholerae. Recent studies have revealed the genetic mechanisms in these bacteria by which new variants of V. cholerae are generated from type-specific strains; these mechanisms suggest that certain strains are selected by environmental or human factors over time. By understanding the mechanisms and driving forces of historical and current changes in the V. cholerae population, it would be possible to predict the direction of such changes and the evolution of new variants; this has implications for the battle against cholera.
URI
https://www.sciencedirect.com/science/article/pii/S0966842X15000773http://repository.hanyang.ac.kr/handle/20.500.11754/101432
ISSN
0966-842X; 1878-4380
DOI
10.1016/j.tim.2015.03.010
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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