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The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study

Title
The Benefits of Combination Therapy with Esomeprazole and Rebamipide in Symptom Improvement in Reflux Esophagitis: An International Multicenter Study
Author
이항락
Keywords
Peptic esophagitis; Symptoms; Heartburn; Rebamipide; Esomeprazole
Issue Date
2016-11
Publisher
EDITORIAL OFFICE GUT & LIVER
Citation
GUT AND LIVER, v. 10, NO 6, Page. 910-916
Abstract
Background/Aims: To investigate the effects of esomeprazole and rebamipide combination therapy on symptomatic improvement in patients with reflux esophagitis. Methods: A total of 501 patients with reflux esophagitis were randomized into one of the following two treatment regimens: 40 mg esomeprazole plus 300 mg rebamipide daily (combination therapy group) or 40 mg esomeprazole daily (monotherapy group). We used a symptom questionnaire that evaluated heartburn, acid regurgitation, and four upper gastrointestinal symptoms. The primary efficacy end point was the mean decrease in the total symptom score. Results: The mean decreases in the total symptom score at 4 weeks were estimated to be -18.1 +/- 13.8 in the combination therapy group and -15.1 +/- 11.9 in the monotherapy group (p=0.011). Changes in reflux symptoms from baseline after 4 weeks of treatment were -8.4 +/- 6.6 in the combination therapy group and -6.8 +/- 5.9 in the monotherapy group (p=0.009). Conclusions: Over a 4-week treatment course, esomeprazole and rebamipide combination therapy was more effective in decreasing the symptoms of reflux esophagitis than esomeprazole monotherapy.
URI
http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl15537http://repository.hanyang.ac.kr/handle/20.500.11754/101257
ISSN
1976-2283; 2005-1212
DOI
10.5009/gnl15537
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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