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Promotion Effects of Ultra-High Molecular Weight Poly-gamma-Glutamic Acid on Wound Healing

Title
Promotion Effects of Ultra-High Molecular Weight Poly-gamma-Glutamic Acid on Wound Healing
Author
이철훈
Keywords
Ultra-high molecular weight poly-gamma-glutamic acid (UHMW gamma-PGA); wound healing; FETAL; FIBROBLASTS; MECHANISMS; EXPRESSION; REPAIR
Issue Date
2015-06
Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
Citation
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v. 25, No. 6, Page. 941-945
Abstract
We examined the in vivo efficacy of ultra-high molecular weight poly-gamma-glutamic acid (UHMW gamma-PGA) for wound healing. The wound area was measured by a ruler and documented by digital photography before the animals were sacrificed at days 8 and 16 post wounding. The areas of wounds treated with UHMW gamma-PGA were significantly decreased on days 8 and 16, as compared with those receiving a control treatment, and more than 70% of the UHMW gamma-PGA-treated area was repaired by day 8. Hematoxylin and eosin staining confirmed that the epidermis had regenerated in the UHMW gamma-PGA-treated wounds. At 16 days post wounding, collagen pigmentation and cross-linking were increased as compared with the control groups, and greater regeneration of blood vessels had occurred in UHMW gamma-PGA-treated groups. Increased levels of transforming growth factor-beta and p-catenin were also observed in skin samples collected from UHMW gamma-PGA-treated animals on days 8 and 16 post incision. Taken together, these findings suggest that UHMW gamma-PGA promotes wound healing in vivo.
URI
http://www.jmb.or.kr/journal/view.html?doi=10.4014/jmb.1412.12083http://repository.hanyang.ac.kr/handle/20.500.11754/100897
ISSN
1738-8872; 1017-7825
DOI
10.4014/jmb.1412.12083
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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