Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오봉경 | - |
dc.date.accessioned | 2019-03-14T05:23:26Z | - |
dc.date.available | 2019-03-14T05:23:26Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | MOLECULES AND CELLS, v. 39, NO. 11, Page. 834-840 | en_US |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2016.0238 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/100787 | - |
dc.description.abstract | Caenorhabditis elegans (C. elegans) utilizes two different cell-cycle modes, binucleations during the L1 larval stage and endoreduplications at four larval moltings, for its postembryonic intestinal development. Previous genetic studies indicated that CDC-25.2 is specifically required for binucleations at the L1 larval stage and is repressed before endoreduplications. Furthermore, LIN-23, the C. elegans β-TrCP ortholog, appears to function as a repressor of CDC-25.2 to prevent excess intestinal divisions. We previously reported that intestinal hyperplasia in lin-23(e1883) mutants was effectively suppressed by the RNAi depletion of cdc-25.2. Nevertheless, LIN-23 targeting CDC-25.2 for ubiquitination as a component of E3 ubiquitin ligase has not yet been tested. In this study, LIN-23 is shown to be the major E3 ubiquitin ligase component, recognizing CDC-25.2 to repress their activities for proper transition of cell-cycle modes during the C. elegans postembryonic intestinal development. In addition, for the first time that LIN-23 physically interacts with both CDC-25.1 and CDC-25.2 and facilitates ubiquitination for timely regulation of their activities during the intestinal development. | en_US |
dc.description.sponsorship | Some C. elegans strains used in this study were provided by the Caenorhabditis Genetic Center, which is supported by the National Institutes of Health, Office of Research Infrastructure Programs (P40 OD010440) and by the C. elegans Reverse Genetics Core Facility at the University of British Columbia, which is part of the international C. elegans Gene Knockout Consortium. We thank Dr. Yuji Kohara (Mishima, Japan) for the yk EST clones. This research was supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education [grant numbers 2013R1A1A2009090 and 2015R1D1A1A01057488 to Y.-H.S., 2015R1D1A1A01057853 to I.K.]. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | en_US |
dc.subject | C. elegans | en_US |
dc.subject | CDC-25.2 | en_US |
dc.subject | E3 ubiquitin ligase | en_US |
dc.subject | intestinal development | en_US |
dc.subject | LIN-23 | en_US |
dc.title | LIN-23, an E3 Ubiquitin Ligase Component, Is Required for the Repression of CDC-25.2 Activity during Intestinal Development in Caenorhabditis elegans. | en_US |
dc.type | Article | en_US |
dc.relation.no | 11 | - |
dc.relation.volume | 39 | - |
dc.identifier.doi | 10.14348/molcells.2016.0238 | - |
dc.relation.page | 834-840 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.contributor.googleauthor | Son, Miseol | - |
dc.contributor.googleauthor | Kawasaki, Ichiro | - |
dc.contributor.googleauthor | Oh, Bong-Kyeong | - |
dc.contributor.googleauthor | Shim, Yhong-Hee | - |
dc.relation.code | 2016002401 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | INSTITUTE FOR THE INTERGRATION OF MEDICINE AND INNOVATIVE TECHNOLOGY | - |
dc.identifier.pid | bongoh0401 | - |
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