Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안주홍 | - |
dc.date.accessioned | 2019-03-14T02:03:31Z | - |
dc.date.available | 2019-03-14T02:03:31Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | MOLECULES AND CELLS, v. 39, NO. 11, Page. 827-833 | en_US |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2016.0222 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/100776 | - |
dc.description.abstract | Regulator of calcineurin 1 (RCAN1) binds to calcineurin through the PxIxIT motif, which is evolutionarily conserved. SP repeat phosphorylation in RCAN1 is required for its complete function. The specific interaction between RCAN1 and calcineurin is critical for calcium/calmodulin-dependent regulation of calcineurin serine/threonine phosphatase activity. In this study, we investigated two available deletion rcan-1 mutants in Caenorhabditis elegans, which proceed differently for transcription and translation. We found that rcan-1 may be required for calcineurin activity and possess calcineurin-independent function in body growth and egg-laying behavior. In the genetic background of enhanced calcineurin activity, the rcan-1 mutant expressing a truncated RCAN-1 which retains the calcineurin-binding PxIxIT motif but misses SP repeats stimulated growth, while rcan-1 lack mutant resulted in hyperactive egg-laying suppression. These data suggest rcan-1 has unknown functions independent of calcineurin, and may be a stimulatory calcineurin regulator under certain circumstances. | en_US |
dc.description.sponsorship | Strains are provided by the Caenorhabditis Genetic Center and National Bioresource Project (NBP-Japan). Kyung-Min Ko performed immunostaining of worms. This work was supported by the Basic Science Research Programs (no. 2015R1D1A1A 01059062) and (2015R1D1A1A01058179) through the National Research Foundation of Korea (NRF) funded by Korean Ministry of Science, ICT & Future Planning. | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | en_US |
dc.subject | calcineurin | en_US |
dc.subject | C. elegans | en_US |
dc.subject | RCAN | en_US |
dc.title | Allele-Specific Phenotype Suggests a Possible Stimulatory Activity of RCAN-1 on Calcineurin in Caenorhabditis elegans | en_US |
dc.type | Article | en_US |
dc.relation.no | 11 | - |
dc.relation.volume | 39 | - |
dc.identifier.doi | 10.14348/molcells.2016.0222 | - |
dc.relation.page | 827-833 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.contributor.googleauthor | Li, Weixun | - |
dc.contributor.googleauthor | Choi, Tae-Woo | - |
dc.contributor.googleauthor | Ahnn, Joohong | - |
dc.contributor.googleauthor | Lee, Sun-Kyung | - |
dc.relation.code | 2016002401 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | joohong | - |
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