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dc.contributor.author홍수진-
dc.date.accessioned2019-03-12T04:33:05Z-
dc.date.available2019-03-12T04:33:05Z-
dc.date.issued2016-10-
dc.identifier.citationEUROPEAN RADIOLOGY,v.26, NO.10, Page. 3660-3668en_US
dc.identifier.issn0938-7994-
dc.identifier.issn1432-1084-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00330-015-4196-z-
dc.identifier.urihttp://repository.hanyang.ac.kr/handle/20.500.11754/100715-
dc.description.abstractTo correlate imaging features of resected lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutation and the IASLC/ATS/ERS classification histological subtypes. In 250 consecutive patients with resected lung adenocarcinoma, EGFR mutation status was correlated with demographics, imaging features including ground-glass opacity (GGO) proportion and the IASLC/ATS/ERS classification histological subtypes. EGFR mutations were significantly more frequent in women (54.5 % vs. 38.1 %, p = 0.011) and in never-smokers (54.7 % vs. 35.3 %, p = 0.003). GGO proportion was significantly higher in tumours with EGFR mutation than in those without (30.3 +/- 33.8 % vs. 19.0 +/- 29.3 %, p = 0.005). EGFR mutation was significantly more frequent in tumours with GGO aeyen 50 % and tumours with any GGO (p = 0.026 and 0.008, respectively). Adenocarcinomas with exon 19 or 21 mutation showed significantly higher GGO proportion than that in EGFR wild-type tumours (p = 0.009 and 0.029, respectively). Absence of GGO was an independent predictor of negative EGFR mutation (odds ratio, 1.81; 95 % confidence interval, 1.16-3.04; p = 0.018). GGO proportion in adenocarcinomas with EGFR mutation was significantly higher than that in EGFR wild-type tumours, and the absence of GGO on CT was an independent predictor of negative EGFR mutation. aEuro cent Ground-glass opacity (GGO) proportion is significantly higher in EGFR-mutated adenocarcinomas aEuro cent Exon 19 or 21 mutated adenocarcinomas shows significantly higher GGO proportion aEuro cent GGO absence is an independent predictor of negative EGFR mutation in lung adenocarcinomas.en_US
dc.description.sponsorshipThe scientific guarantor of this publication is Tae Jung Kim, MD, PhD. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This work was supported by grant no 02-2011-002 from the Seoul National University Bundang Hospital Research Fund. One of the authors has significant statistical expertise. Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board. Methodology: retrospective, observational, performed at one institution.en_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.subjectComputed tomography (CT)en_US
dc.subjectLungen_US
dc.subjectAdenocarcinomaen_US
dc.subjectEpidermal growth factor receptor (EGFR)en_US
dc.subjectMutationen_US
dc.titleRadiogenomic Correlation in Lung Adenocarcinoma with Epidermal Growth Factor Receptor Mutations: Imaging Features and Histological Subtypesen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00330-015-4196-z-
dc.relation.page3660-3668-
dc.relation.journalEUROPEAN RADIOLOGY-
dc.contributor.googleauthorHong, Su Jin-
dc.contributor.googleauthorKim, Tae Jung-
dc.contributor.googleauthorChoi, Yo Won-
dc.contributor.googleauthorPark, Jeong-Soo-
dc.contributor.googleauthorChung, Jin-Haeng-
dc.contributor.googleauthorLee, Kyung Won-
dc.relation.code2016003581-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidsjhrad-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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