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Review: Laboratory Diagnosis and Surveillance of Creutzfeldt-Jakob Disease

Title
Review: Laboratory Diagnosis and Surveillance of Creutzfeldt-Jakob Disease
Author
류종석
Keywords
Creutzfeldt-Jakob disease; transmissible spongiform encephalopathy; prion disease; surveillance; diagnosis; HUMAN PRION DISEASES; TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES; CENTRAL-NERVOUS-SYSTEM; QUAKING-INDUCED CONVERSION; SHARP WAVE COMPLEXES; CEREBROSPINAL-FLUID; DIFFERENTIAL-DIAGNOSIS; 14-3-3 PROTEIN; ALZHEIMERS-DISEASE; VARIANT
Issue Date
2015-01
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF MEDICAL VIROLOGY, v. 87, No. 1, Page. 175-186
Abstract
Creutzfeldt-Jakob disease (CJD) is a representative human transmissible spongiform encephalopathy associated with central nervous system degeneration. Prions, the causative agents of CJD, are composed of misfolded prion proteins and are able to self-replicate. While CJD is a rare disease affecting only 1-1.5 people per million worldwide annually, it has attracted both scientific and public attention as a threatening disease since an epidemic of variant CJD (vCJD) cases appeared in the mid-1990s. Due to its unconventional transmission and invariable fatality, CJD poses a serious risk to public health. The hundreds of sporadic, genetic, and iatrogenic CJD cases as well as potential zoonotic transmission suggest that CJD is an ongoing concern for the field of medicine. Nevertheless, treatment aimed at clinical prevention and treatment that reverses the course of disease does not exist currently. Active surveillance and effective laboratory diagnosis of CJD are, therefore, critical. In this report, the surveillance systems and laboratory tests used currently to diagnose CJD in different countries are reviewed. The current efforts to improve surveillance and diagnosis for CJD using molecular and biochemical findings are also described. J. Med. Virol. 87: 175-186, 2015. (c) 2014 Wiley Periodicals, Inc.
URI
http://onlinelibrary.wiley.com/doi/10.1002/jmv.24004/fullhttp://repository.hanyang.ac.kr/handle/20.500.11754/100630
ISSN
0146-6615; 1096-9071
DOI
10.1002/jmv.24004
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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