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Uniform and stable hydrogel-filled liposome-analogous vesicles with a thin elastomer shell layer

Title
Uniform and stable hydrogel-filled liposome-analogous vesicles with a thin elastomer shell layer
Author
김진웅
Keywords
Vesicle; Microfluidics; Elastomer film; Impermeability
Issue Date
2016-10
Publisher
ELSEVIER SCIENCE BV
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, v. 146, Page. 544-549
Abstract
This study introduces a new type of uniform liposome-analogous vesicle with a highly stable shell structure in which water-in-oil-in-water double emulsion drops fabricated in a capillary-based microfluidic device are used as templates. The vesicles developed in this work consist of a poly(ethylene glycol) hydro gel core surrounded by a polyurethane (PU) film between 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) layers. Subjecting the double emulsion templates to UV irradiation leads to the formation of a PU elastomer film between the DPPC layers. The presence of a thin PU film sandwiched between the DPPC layers is confirmed by confocal laser microscopy. The thicknesses of the PU films are measured to be approximately similar to 4 mu m. Further study reveals the incorporation of the PU film between the DPPC layers remarkably improves the shell impermeability. Our vesicle system is expected to be useful for regulating the permeation of small molecules through lipid -based vesicular films. (C) 2016 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0927776516304829?via%3Dihubhttp://repository.hanyang.ac.kr/handle/20.500.11754/100462
ISSN
0927-7765; 1873-4367
DOI
10.1016/j.colsurfb.2016.06.052
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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