TY - JOUR AU - 최한곤 DA - 2008/02 PY - 2008 UR - https://link.springer.com/article/10.1007/s12272-001-1148-8 UR - https://repository.hanyang.ac.kr/handle/20.500.11754/76818 AB - The aim was to evaluate the skin permeation and accumulation profiles of a highly lipophilic fatty ester using the combination of various permeation enhancing techniques to study the potential of highly lipophilic fatty esters as local topical agents. Permeation and accumulation profiles of ketorolac stearate (C18:0) were studied using solubility improved formulation, supersaturated solution of permeant in enhancer vehicle, lipophilic receptor solution, enhancer pretreatment, and the removal of stratum corneum and delipidization of skins. Impermeability and minimal skin accumulation of ketorolac stearate could delineate a preliminary possibility for designing safer topical agents without systemic absorption. PB - PHARMACEUTICAL SOCIETY KOREA KW - fatty esters KW - ketorolac stearate KW - skin permeation KW - skin accumulation KW - local topical agent TI - Evaluation of skin permeation and accumulation profiles of a highly lipophilic fatty ester VL - 31 DO - 10.1007/s12272-001-1148-8 T2 - ARCHIVES OF PHARMACAL RESEARCH ER -