TY - JOUR AU - ์กฐ์„ํ˜„ DA - 2016/06 PY - 2016 UR - http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156979 UR - https://repository.hanyang.ac.kr/handle/20.500.11754/72632 AB - Background Allergic rhinitis (AR) is the most common allergic disease but little is known about the difference of local immune responses in children and adults with AR. Objective To compare local immune responses between children and adults with AR and nonallergic rhinitis (NAR), and to investigate whether the association of local and systemic immune responses is different between the two age groups. Methods Fifty-one patients with chronic rhinitis were enrolled and grouped into children (N = 27, mean age 7.2 years) and adults (N = 24, mean age 29.9 years). Diagnosis of AR was based on symptoms, skin prick tests and serum specific IgEs. Nasal lavage (NAL) fluids were collected from all subjects and used to measure the levels of total IgE, specific IgEs to house dust mites (Dp and Df), and cytokines (TNF-alpha, IL-4, IL-10, IL-17A and IFN-gamma). Flow cytometry was used to measure inflammatory cell types in NAL fluids. Results AR had significantly increased local levels of total IgE and specific IgEs to Dp and Df compared with NAR in both age groups (P ห‚ 0.05). Nasal eosinophils %(P = 0.01) was significantly increased only in children with AR. Local-systemic correlations of total IgE (r = 0.662, P = 0.000) and eosinophil %(r = 0.461, P = 0.015) between the peripheral blood and NAL fluids were found only in children. Moreover, children had correlations between total IgE and eosinophil % in the peripheral blood (r = 0.629, P = 0.001) and in NAL fluids (r = 0.373, P = 0.061). Conclusion Elevated local IgE is a common feature of AR in children and adults. Local measures in NAR showed naive state of immune response which disagree with the hypothesis of local allergic rhinitis. Children showed intense local inflammation and close local-systemic interactions compared to adults supporting pediatric AR as a distinct feature. PB - PUBLIC LIBRARY SCIENCE KW - IDIOPATHIC RHINITIS KW - IGE ANTIBODIES KW - REGULATORY-T KW - GRASS-POLLEN KW - B-CELLS KW - PREVALENCE KW - ASTHMA KW - ABSENCE KW - MODEL KW - SKIN TI - Local Immune Responses in Children and Adults with Allergic and Nonallergic Rhinitis IS - 6 VL - 11 DO - 10.1371/journal.pone.0156979 T2 - PLOS ONE ER -