TY - JOUR AU - 최한곤 DA - 2017/03 PY - 2017 UR - http://www.mdpi.com/1420-3049/22/2/280/htm UR - https://repository.hanyang.ac.kr/handle/20.500.11754/71999 AB - The aim of this work was to develop cefdinir solid dispersions (CSDs) prepared using hydrophilic polymers with enhanced dissolution/solubility and in vivo oral bioavailability. CSDs were prepared with hydrophilic polymers such as hydroxypropyl-methylcellulose (HPMC; CSD1), carboxymethylcellulose-Na (CMC-Na; CSD2), polyvinyl pyrrolidone K30 (PVP K30; CSD3) at the weight ratio of 1:1 (drug:polymer) using a spray-drying method. The prepared CSDs were characterized by aqueous solubility, differential scanning calorimetry (DSC), powder X-ray diffraction (p-XRD), scanning electron microscopy (SEM), aqueous viscosity, and dissolution test in various media. The oral bioavailability of CSDs was also evaluated in rats and compared with cefdinir powder suspension. The cefdinir in CSDs was amorphous form, as confirmed in the DSC and p-XRD measurements. The developed CSDs commonly resulted in about 9.0-fold higher solubility of cefdinir and a significantly improved dissolution profile in water and at pH 1.2, compared with cefdinir crystalline powder. Importantly, the in vivo oral absorption (represented as AUCinf) was markedly increased by 4.30-, 6.77- and 3.01-fold for CSD1, CSD2, and CSD3, respectively, compared with cefdinir suspension in rats. The CSD2 prepared with CMC-Na would provide a promising vehicle to enhance dissolution and bioavailability of cefdinir in vivo. PB - MDPI AG KW - TGFBI wt Allele KW - cefdinir KW - hypromellose KW - Calorimetry, Differential Scanning KW - Scanning Electron Microscopy KW - Carboxymethylcellulose Sodium KW - Biological Availability KW - Povidone KW - Calorimetry KW - Povidone-Iodine KW - Methylcellulose KW - Polyvinyls KW - Sodium KW - Desiccation KW - Polymers KW - Polyvinyl Chloride TI - Cefdinir Solid Dispersion Composed of Hydrophilic Polymers with Enhanced Solubility, Dissolution, and Bioavailability in Rats IS - 2 VL - 22 DO - 10.3390/molecules22020280 T2 - MOLECULES ER -