TY - JOUR AU - 류재숙 DA - 2011/03 PY - 2011 UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671398 UR - https://repository.hanyang.ac.kr/handle/20.500.11754/69582 AB - Mast cells have been reported to be predominant in the vaginal smears of patients infected with T. vaginalis. In this study, we investigated whether T. vaginalis could induce mast cells to migrate and to produce TNF-alpha and histamine. Rat peritoneal mast cells (RPMC), a primary mast cell, were used for the study. T. vaginalis induced an increase in chemotactic migration of the mast cells toward excretory and secretory product (ESP) of T. vaginalis, and the mast cells activated with T. vaginalis showed an increased release of histamine and TNF-alpha. Therefore, mast cells may be involved in the inflammatory response caused by T. vaginalis. PB - EDP SCIENCES S A, 17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A, FRANCE KW - Trichomonas vaginalis KW - rat KW - mast cell KW - migration KW - histamine KW - TNF-alpha KW - TUMOR-NECROSIS-FACTOR KW - IMMUNE-RESPONSE KW - IN-VIVO KW - INFECTION KW - ASSOCIATION KW - MIGRATION KW - HEPARIN KW - MOUSE KW - MICE TI - Histamine and TNF-a release by rat peritoneal mast cells IS - 1 VL - 18 T2 - PARASITE-JOURNAL DE LA SOCIETE FRANCAISE DE PARASITOLOGIE ER -