TY - JOUR AU - 최재훈 DA - 2015/12 PY - 2015 UR - http://www.nature.com/onc/journal/v34/n50/full/onc201554a.html?foxtrotcallback=true UR - http://hdl.handle.net/20.500.11754/29623 AB - Extracellular Matrix Protein 1 (ECM1) is a marker for tumorigenesis and is correlated with invasiveness and poor prognosis in various types of cancer. However, the functional role of ECM1 in cancer metastasis is unclear. Here, we detected high ECM1 level in breast cancer patient sera that was associated with recurrence of tumor. The modulation of ECM1 expression affected not only cell migration and invasion, but also sphere-forming ability and drug resistance in breast cancer cell lines. In addition, ECM1 regulated the gene expression associated with the epithelial to mesenchymal transition (EMT) progression and cancer stem cell (CSC) maintenance. Interestingly, ECM1 increased beta-catenin expression at the post-translational level through induction of MUC1, which was physically associated with beta-catenin. Indeed, the association between beta-catenin and the MUC1 cytoplasmic tail was increased by ECM1. Furthermore, forced expression of beta-catenin altered the gene expression that potentiated EMT progression and CSC phenotype maintenance in the cells. These data provide evidence that ECM1 has an important role in cancer metastasis through beta-catenin stabilization. PB - NATURE PUBLISHING GROUP KW - EXTRACELLULAR-MATRIX PROTEIN-1 KW - NF-KAPPA-B KW - EPITHELIAL-MESENCHYMAL TRANSITION KW - BREAST-CANCER CELLS KW - STEM-CELLS KW - LYMPHATIC METASTASIS KW - SIGNALING PATHWAYS KW - INITIATING CELLS KW - SELF-RENEWAL KW - EXPRESSION TI - ECM1 regulates tumor metastasis and CSC-like property through stabilization of beta-catenin IS - 50 VL - 34 DO - 10.1038/onc.2015.54 T2 - ONCOGENE ER -