TY - JOUR AU - 신진호 DA - 2015/09 PY - 2015 UR - http://online.liebertpub.com/doi/abs/10.1089/jwh.2015.5358 UR - http://hdl.handle.net/20.500.11754/27426 AB - Background: Inconsistent results regarding the association between low vitamin D level and hypertension (HTN) have led to uncertainty in clinical practice as to the use of vitamin D cutoff value. The aims of this study were to investigate the association between vitamin D deficiency and HTN in postmenopausal women and to determine the clinically significant cutoff value for vitamin D deficiency. Methods: We analyzed data from the Korean National Health and Nutrition Examination Survey 5 database (4107 postmenopausal women, aged 50-79 years). The cutoff value for vitamin D deficiency was based on the changes in parathyroid hormone (PTH) level according to serum 25(OH)D value. Results: PTH levels were significantly higher in groups with serum 25(OH)D <15ng/mL (p<0.001). When a serum 25(OH)D value of 15ng/mL was used as a cutoff value, 35.2% of the subjects were found to be vitamin D deficient. Although the association between 25(OH)D level <15ng/mL and systolic blood pressure did not remain significant after adjusting for season (p=0.30), multiple logistic regression analysis revealed that 25(OH)D level <15ng/mL was an independent risk factor for HTN (adjusted odds ratio [OR] 1.285, 95% confidence interval [CI] 1.024-1.614, p=0.031). Conclusions: Using serum PTH level, we defined vitamin D deficiency as 25(OH)D <15ng/mL in postmenopausal women. Vitamin D deficiency [25(OH)D <15ng/mL] was a significant risk factor for HTN in postmenopausal women. PB - Mary Ann Liebert KW - NUTRITION EXAMINATION SURVEY KW - PARATHYROID-HORMONE LEVELS KW - GENOME-WIDE ASSOCIATION KW - BODY-FAT DISTRIBUTION KW - BLOOD-PRESSURE KW - NATIONAL-HEALTH KW - D SUPPLEMENTATION KW - SERUM 25-HYDROXYVITAMIN-D KW - 1,25-DIHYDROXYVITAMIN D-3 KW - HYPOVITAMINOSIS D TI - Defining vitamin D deficiency and its relationship to hypertension in postmenopausal Korean women DO - 10.1089/jwh.2015.5358 T2 - Journal of Women's Health ER -