TY - JOUR AU - 윤소원 DA - 2019/02 PY - 2019 UR - https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201801265 UR - https://repository.hanyang.ac.kr/handle/20.500.11754/108475 AB - A palladium-catalyzed aerobic C-H amidation of N-Ts-2-amino-3 '-hydroxylbiaryls has been developed to afford a diverse range of 1-hydroxycarbazoles with high regioselectivity and efficiency. This protocol benefits from operational simplicity, robustness, and sustainability with the use of ambient air as the sole terminal oxidant. Further elaboration of the products obtained from this process provides facile access to various carbazole alkaloids including carbazolequinones and biscarbazoles. A mechanism involving dual directing group-assisted regioselective C-H activation at the more sterically hindered C2 '-position of 2-amino-3 '-hydroxylbiaryls is proposed. PB - WILEY-V C H VERLAG GMBH KW - carbazoles KW - C-H activation KW - palladium catalysis KW - regioselectivity TI - Palladium-Catalyzed Regioselective Synthesis of 1-Hydroxycarbazoles Under Aerobic Conditions IS - 3 VL - 361 DO - 10.1002/adsc.201801265 T2 - ADVANCED SYNTHESIS & CATALYSIS ER -