최한곤
2018-12-06T04:59:14Z
2018-12-06T04:59:14Z
2008-11
ARCHIVES OF PHARMACAL RESEARCH, v. 31, No. 11, Page. 1497-1507
0253-6269
https://link.springer.com/article/10.1007/s12272-001-2136-8
https://repository.hanyang.ac.kr/handle/20.500.11754/80755
To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared, characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR), and evaluated for solubility, and in-vitro ibuprofen release. Loss of individual surface properties during melting and re-solidification as revealed by SEM micrographs indicated the formation of effective SDs. Absence or shifting towards the lower melting temperature of the drug peak in SDs and physical mixtures in DSC study indicated the possibilities of drug-polymer interactions. FTIR spectra showed the presence of drug crystalline in SDs. The effect of improved dissolution on the oral absorption of ibuprofen in rats was also studied. Quicker release of ibuprofen from SDs in rat intestine resulted in a significant increase in AUC and C-max, and a significant decrease in T-max over pure ibuprofen. Comparison of the enhanced solubility, dissolution, AUC, and C-max of ibuprofen from different poloxamers suggested that the preparation of ibuprofen SDs using P 407 as a meltable hydrophilic polymer carrier could be a promising approach to improve its solubility, dissolution and absorption rate.
This research was supported by the Yeungnam University research grants in 2007.
en_US
PHARMACEUTICAL SOCIETY KOREA
Ibuprofen
Solid dispersions
Poloxamers
Solubility
Dissolution
Bioavailability
Enhanced Dissolution of Ibuprofen Using Solid Dispersion with Poloxamer 407
Article
31
10.1007/s12272-001-2136-8
1497-1507
ARCHIVES OF PHARMACAL RESEARCH
Newa, Madhuri
Bhandari, Krishna Hari
Oh, Dong Hoon
Kim, Young Ran
Sung, Joon Ho
Kim, Jong Oh
Woo, Jong Soo
Choi, Han Gon
Yong, Chul Soon
2008200969
E
COLLEGE OF PHARMACY[E]
DEPARTMENT OF PHARMACY
hangon