이주연
2019-04-29T02:02:46Z
2019-04-29T02:02:46Z
2016-10
CARDIOVASCULAR THERAPEUTICS, v. 34, No. 4, Page. 268-275
1755-5914
1755-5922
https://onlinelibrary.wiley.com/doi/full/10.1111/1755-5922.12197
https://repository.hanyang.ac.kr/handle/20.500.11754/102850
Aim Potential heterogeneity within the same class of drug in terms of persistence may lead to different clinical implications. Given that the increased risks of mortality and cardiovascular events are due, in part, to the lack of persistent use of antihypertensive medications, the objective of this study was to evaluate 1-year persistence of new-generation beta blockers compared to atenolol in antihypertensive treatment-naive patients. Methods A total of 9978 patients aged 18years or older with hypertension newly diagnosed in 2012, without hypertension-related complication and initiated treatment with beta blocker monotherapy during 2012 were included in the analysis. Rate and duration of treatment and drug persistence were compared between atenolol and new-generation beta blockers. Hazards of discontinuation in nonatenolol compared to atenolol were evaluated using a multivariate Cox proportional model. Results The rate of treatment persistence was higher in the nonatenolol group (57.35% vs 53.40%, P<.0001), and the time to treatment discontinuation was earlier in the atenolol group with a minimal difference in the average (243.2 vs 254days, P<.0001). New-generation beta blockers demonstrated a lower risk of treatment discontinuation (HR: 0.91, 95% CI: 0.86-0.96) compared to atenolol; a notable improvement was observed with carvedilol and nebivolol (HR: 0.74, 95% CI: 0.69-0.80 and HR: 0.79, 95% CI: 0.70-0.89, respectively), whereas betaxolol showed a substantially greater hazard for discontinuation compared to atenolol. Conclusions This study demonstrated a meaningful improvement in treatment persistence with new-generation beta blockers compared to atenolol, with betaxolol as exception.
This work was supported by the Ministry of Health & Welfare (MOHW, Korea) [Project Name: A study on the improvement of drug safety for pharmaceutical care disparities in Korea]. However, design, analysis, data collection, and the interpretation of results were solely performed by each author listed.
en_US
WILEY-BLACKWELL
adherence
atenolol
betaxolol
new-generation beta blocker
persistence
RETROSPECTIVE CLAIMS ANALYSIS
MEDICATION ADHERENCE
ANTIHYPERTENSIVE THERAPY
HYPERTENSIVE PATIENTS
BLOOD-PRESSURE
DRUG CLASS
DISCONTINUATION
NEBIVOLOL
Implication of different initial beta blockers on treatment persistence: atenolol vs new-generation beta blocker, a population-based study
Article
4
34
10.1111/1755-5922.12197
268-275
CARDIOVASCULAR THERAPEUTICS
Choi, Yun Jung
Ah, Young-Mi
Kong, Jisun
Choi, Kyung Hee
Kim, Baegeum
Han, Nayoung
Yu, Yun Mi
Oh, Jung Mi
Shin, Wan Gyoon
Lee, Ju-Yeun
Lee, Hae-Young
2016001209
E
COLLEGE OF PHARMACY[E]
DEPARTMENT OF PHARMACY
jypharm