김상성
2018-03-26T06:31:43Z
2018-03-26T06:31:43Z
2016-04
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, V. 2016, Article ID 8793095
1741-427X
1741-4288
https://www.hindawi.com/journals/ecam/2016/8793095/abs/
http://hdl.handle.net/20.500.11754/52453
ESP-102, an extract from Angelica gigas, Saururus chinensis, and Schisandra chinensis, has been used as herbal medicine and dietary supplement in Korea. Despite the numerous bioactivities in vitro and in vivo studies, its effects on neuronal networks remain elusive. To address the neuronal effect, we examined synaptic plasticity in organotypic hippocampal slice culture with multielectrode array. Our results showed an increase in excitatory postsynaptic potential (EPSP), indicating the induction of long-term potentiation (LTP), in the presence of ESP-102. In addition, the neuroprotective effect of ESP-102 was also tested by application of scopolamine to the hippocampal slice. Interestingly, ESP-102 competitively antagonized the preventative LTP effect induced by scopolamine. The scopolamine-induced reduction in brain-derived neurotrophic factor (BDNF) and GluR-2 expression was also rescued by ESP-102. In terms of mode of action, ESP-102 appears to act on the presynaptic region independent of AMPA/NMDA receptors. Based on these findings, ESP-102 can be suggested as a novel herbal ingredient with memory enhancing as well as neuroprotective effects.
This work was supported by a grant from Kyung Hee University in 2012 (KHU-2012 0575).
en_US
HINDAWI PUBLISHING CORP
LONG-TERM POTENTIATION
GLUTAMATE UPTAKE
MICE
STIMULATION
INVOLVEMENT
DEPRESSION
RECEPTORS
CULTURES
SLICES
LTP
ESP-102, a Combined Herbal Extract of Angelica gigas, Saururus chinensis, and Schisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue
Article
10.1155/2016/8793095
1-23
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
Kim, Hyun-Bum
Hwang, Eun-Sang
Choi, Ga-Young
Lee, Seok
Park, Tae-Suk
Lee, Cheol-Won
Lee, Eun-Suk
Kim, Young-Choong
Kim, Sang Seong
Lee, Sung-Ok
Park, Ji-Ho
2016006715
E
COLLEGE OF PHARMACY[E]
DEPARTMENT OF PHARMACY
talpiot