민경환
2018-03-21T08:07:31Z
2018-03-21T08:07:31Z
2012-09
Japanese Journal of Infectious Diseases, 2012, 65(3), P.193-197
1344-6304
https://www.jstage.jst.go.jp/article/yoken/65/3/65_193/_article
http://hdl.handle.net/20.500.11754/50177
The first large-scale outbreaks of respiratory disease in the 21st century were caused by the influenza A (H1N1) virus in 2009, which affected mostly young adults. The M59 vaccine was developed to control pandemic influenza A (H1N1). However, the complications arising from the use of the non-adjuvanted and adjuvanted vaccines in young male Korean soldiers have not previously been evaluated and compared. We conducted a prospective multicenter study of 2,864 healthy male soldiers aged 19 to 25 years to evaluate the adverse events associated with both the MF59-adjuvanted and non-adjuvanted forms of the influenza A/California/2009 (H1N1) surface-antigen vaccine. In most cases, the adverse-event symptoms were mild, and the most frequent adverse events were swelling at the injection site and myalgia, which were noted in 4.8% and 10.7% of participants, respectively. Administration of the MF59-adjuvanted vaccine was associated with an increased incidence of local (crude odds ratio [cOR], 1.56; 95% confidence interval [CI], 1.11-2.29) and systemic adverse events (cOR, 1.64; 95% CI, 1.29-2.07) after vaccination. Atopic dermatitis (adjusted OR [aOR], 2.32; 95% CI, 0.99-5.46) might be the choice risk factor for local adverse events, and adjuvant use (aOR, 1.35; 95% CI, 1.03-1.78) was a significant predictor of systemic adverse events in healthy young male Korean soldiers.
en
Institute of Infectious Diseases
INFLUENZA-VIRUS
IMMUNOGENICITY
SAFETY
INFECTION
MF59; DIPHTHERIA
RESPONSES
CHILDREN
ANTIBODY
TETANUS
Comparison of the adverse events associated with MF59-adjuvanted and non-adjuvanted H1N1 vaccines in healthy young male Korean soldiers
Article
10.7883/yoken.65.193
JAPANESE JOURNAL OF INFECTIOUS DISEASES
Hwang, Se-Min
Kim, Hack-Lyoung
Min, Kyueng-Whan
Kim, Min
Lim, Jae-Sung
Choi, Jin-Man
Chun, Byung-Chul
Kim, Min-Jeong
Lee, Sang-Min
Kim, Seung-Young
2012204511
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
kyueng