김용주
2018-03-29T02:37:24Z
2018-03-29T02:37:24Z
2014-12
Pediatric Gastroenterology, Hepatology & Nutrition, 17(4), p.232-238
2234-8646
https://synapse.koreamed.org/DOIx.php?id=10.5223/pghn.2014.17.4.232
http://hdl.handle.net/20.500.11754/53596
Purpose: This study investigated the clinical presentations of symptomatic Clostridium difficile infection (CDI) in children. Methods: We reviewed the medical records of 43 children aged <20 years who showed either positive C. difficileculture or C. difficile toxin test results between June 2010 and April 2014. Results: Of the 43 patients (mean age 6.7 years), 22 were boys. Sixteen patients (37.2%) showed both positive C. difficile culture and toxin test results. Seventeen out of 43 children (39.5%) had preexisting gastrointestinal dis-eases, and 26 children had other medical conditions that were risk factors for CDI. Twenty-eight children had a history of antibiotic treatment for >3 days, and the most frequently prescribed antibiotic was amoxicillin-clavulanate (35.7%). Twenty-eight patients were diagnosed with CDI despite taking probiotic supplements, most commonly Lactobacillus acidophilus (53.6%). The most common symptom was diarrhea (72.1%) at the time CDI was diagnosed. C. difficilewas eradicated in 11 patients (25.6%) after treatment with oral metronidazole for 10-14 days, and in the two patients (4.6%) who required two courses of oral metronidazole. Sixteen patients (37.2%) showed clinical improvement with-out any treatment. Conclusion: This study showed the various clinical characteristics of CDI in children and that preexisting clinical conditions favored the development of CDI. In addition, CDI was found to occur in a number of patients even after probiotic prophylaxis given in conjunction with antibiotic therapy.
en
The Korean Society of Pediatric Gastroenterology
Clostridium difficile
Probiotics
Child
Diarrhea
Clinical Characteristics of Symptomatic Clostridium difficile Infection in Children: Conditions as Infection Risks and Whether Probiotics Is Effective
Article
4
17
10.5223/pghn.2014.17.4.232
232-238
Pediatric Gastroenterology, Hepatology & Nutrition
Na, Jae Yoon
Park, Jong Mo
Lee, Kyung Suk
Kang, Jung Oak
Oh, Sung Hee
Kim, Yong Joo
2014001313
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
kyjoo