전대원
2018-03-23T07:47:03Z
2018-03-23T07:47:03Z
2014-11
대한소화기학회지, 권: 64, 호: 4, 페이지: 182-188
1598-9992
https://www.synapse.koreamed.org/search.php?where=aview&id=10.4166/kjg.2014.64.4.182&code=0028KJG&vmode=FULL
http://hdl.handle.net/20.500.11754/51551
Cell death is an integral part of life of an organism that is necessary to maintain organs and tissues. Apoptosis, autophagy, and necrosis were noted as three morphologically distinct types of cell death. Apoptosis is a well identified process that is driven by programmed molecular mechanism. Until now, the investigators believed that necrosis was not a programmed molecular event. However, recently, an alternative death pathway called 'necroptosis' was delineated and proposed as a form of 'programmed necrosis'. According to the recent recommendations by the Nomenclature Committee of Cell Death, this term denotes necrotic cell death dependent on receptor-interacting protein kinase (RIPK3). Its role in a variety of diseases, such as ischemia-perfusion injury, infection, inflammatory bowel disease, pancreatitis, steatohepatitis etc., is being elucidated. Necroptosis is currently attracting the attention of the scientific community. Herein we discuss the clinical implications and the role of necroptosis in gastrointestinal tract focusing on liver and pancreatic diseases.
en
The Korean Society Of Gastroenterology
Cell death
Necroptosis
Necrosis
Receptor-interacting protein kinase
Tumor necrosis factor-alpha
Necroptosis in Liver and Pancreatic Diseases
간, 췌장 질환에서 Necroptosis
Article
4
64
10.4166/kjg.2014.64.4.182
182-188
The Korean journal of gastroenterology
윤재훈
전대원
최호순
2012211627
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
noshin