Klaus Heese
2018-03-24T06:26:54Z
2018-03-24T06:26:54Z
2014-02
FEMS MICROBIOLOGY LETTERS; FEB 2014, 351, 1, p59-p63
0378-1097
https://academic.oup.com/femsle/article/351/1/59/501726
http://hdl.handle.net/20.500.11754/51858
Although GlaxoSmithKline is on the way to launch the new vaccine candidate RTS, S', the search for suitable antimalarial drugs still remains an exceeding challenge because Plasmodium falciparum-mediated malaria is one of the most lethal diseases in the world. Novel innovative ideas are required to identify new potential molecular targets to be able to fight this lethal parasite efficiently. We used an unconventional bioinformatics approach to analyze the entire genome and proteome of the Pf3D7 strain. Because the oxygen (O-) content is a decisive parameter that determines the function of a protein, we analyzed the entire Pf3D7 proteome based on O-containing amino acid expression. Our data disclose a total of four proteins encoded by chromosome (Chr)-4 and Chr-9 that have an outstanding O-controlled character. The identification of the biological significance of these proteins could eventually lead to new vital drug targets.
We thank Dr. Rajasekaran Ekambaram for helpful discussions. This study was supported by Hanyang University. The authors declare no competing interests.
en
WILEY-BLACKWELL
malaria
oxygen
nitrogen
sulfur
Oxygen distribution in proteins defines functional significance of the genome and proteome of the malaria parasite Plasmodium falciparum 3D7
Article
1
351
10.1111/1574-6968.12355
59-63
FEMS MICROBIOLOGY LETTERS
Palanisamy, Balamurugan
Heese, Klaus
2014029586
S
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S]
klaus