이창호
2018-01-31T04:25:00Z
2018-01-31T04:25:00Z
2011-02
Molecules and Cells, 2011, 31(2), P.159-164(6)
1016-8478
https://link.springer.com/article/10.1007%2Fs10059-011-0019-5
Histone deacetylase inhibitors (HDACIs) that modulate gene expression by inhibiting HDAC enzymes may contribute to the survival of immature hippocampal neurons. However, it remains unknown how and when HDACIs regulate the survival of newly generated immature hippocampal neurons. In the present study, if the treatment of valproic acid (VPA) and sodium butyrate (SBt) in the specific time window during the development of newly generated n eurons r esulted in the i ncreased survival of bromodeoxyuridine (BrdU)(+) neurons in the dentate gyrus (DG) of hippocampus in mice was investigated. It was found that the number of BrdU(+) cells, the expressions of anti-apoptotic Bcl-2 family members and pCREB [D1] were increased by HDACIs when HDACIs were treated no later than 2-3 weeks after BrdU labeling. This suggests that epigenetic modification within a specific time window is critical for the survival of newborn hippocampal neurons by inhibiting the apoptotic pathway.
Korea Science & Engineering Foundation, Ministry of Science and Technology, Republic of Korea
ko_KR
Korean SOC Molecules Cellular Biology
HDAC
neurogenesis
survival
valproate
A critical time window for the survival of neural progenitor cells by HDAC inhibitors in the hippocampus
Article
2
31
10.1007/s10059-011-0019-5
159-164
MOLECULES AND CELLS
Kim, Byung-Woo
Yang, Sera
Lee, Chang Ho
Son, Hyeon
2011206841
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
jennysue