최보율
2017-11-27T06:01:09Z
2017-11-27T06:01:09Z
2016-02
NUTRITION, v. 32, NO 10, Page. 1048-1056
0899-9007
1873-1244
http://www.sciencedirect.com/science/article/pii/S0899900716001210?via%3Dihub
http://hdl.handle.net/20.500.11754/31873
Objective: There has been increasing interest in non-skeletal interactions between vitamin D insufficiency, which is common, and cardiovascular event and cardiovascular disease (CVD) risk factors. Methods: To evaluate cross-sectional associations between dietary and serum vitamin D status and metabolic abnormalities and arterial changes among 1054 adults aged ˃= 40 y (404 men and 650 women) in a rural area of South Korea. Study subjects were divided into three groups according to dietary vitamin D intake (tertiles) measured by food frequency questionnaire and serum 25(OH)D levels (˂= 20, 21-29, and ˃= 30 ng/mL). Metabolic components (blood pressure, lipid profiles, and glycemic index) and arterial changes (brachial ankle pulse wave velocity [baPWV] and carotid artery intima-media wall thickness [cIMT]) were measured. Results: Dietary vitamin D was inversely associated with diastolic blood pressure (DBP) and baPWV among men, but the association disappeared after multinutrient supplement users were excluded. Among women, there was an inverse association between dietary vitamin D and triacylglycerol (TG) levels. However, serum 25(OH)D showed a significant positive relationship with HDL cholesterol in both men and women, while a positive linear trend or nonlinear trend with serum 25(OH)D levels was shown in TG levels among men and in systolic blood pressure (SBP), DBP, total cholesterol, and baPWV among women. The positive relationship between serum 25(OH)D with baPWV disappeared after adjustment for blood pressure. Conclusions: Serum 25(OH)D may be favorably related to HDL cholesterol. However, serum 25(OH) D may not favorably related to subclinical atherosclerosis and arterial stiffness measured by cIMT and baPWV. The positive relationship between 25(OH)D and baPWV is likely to be mediated by blood pressure. (C) 2016 Elsevier Inc. All rights reserved.
This study was supported by the National Research Foundation of Korea (grant NRF-2012 R1 A1 A2001930) and a fund (grants 2004-E71004-00, 2005-E71011-00, 2006-E71009-00, 2007-E71002-00, 2008-E71004-00, and 2009-E71006-00) of the Research of Korea Centers for Disease Control and Prevention.
en
ELSEVIER SCIENCE INC
Dietary vitamin D
Serum 25(OH)D
Cardiometabolic risk factors
Subclinical atherosclerosis
Arterial stiffness
The cross-sectional relationships of dietary and serum vitamin D with cardiometabolic risk factors: Metabolic components, subclinical atherosclerosis, and arterial stiffness
Article
10
32
10.1016/j.nut.2016.02.019
1048-1056
NUTRITION
Kang, Ji Yeon
Kim, Mi Kyung
Jung, Sukyoung
Shin, Jinho
Choi, Bo Youl
2016003655
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
bychoi