신진호
2017-05-16T01:29:58Z
2017-05-16T01:29:58Z
2015-09
AMERICAN JOURNAL OF CARDIOLOGY, v. 116, NO 5, Page. 717-724
0002-9149
1879-1913
http://www.sciencedirect.com/science/article/pii/S0002914915014253
http://hdl.handle.net/20.500.11754/27323
As it is controversial whether metabolic syndrome (MetS) affects cardiovascular outcomes in patients who underwent percutaneous coronary intervention (PCI), we investigated the impact of MetS on clinical outcomes in patients who underwent PCI with everolimus-eluting stents (EESs). Patients who underwent PCI with EESs from 2009 to 2013 were included in this single-center, prospective cohort study. A composite event consisted of repeat revascularization, nonfatal myocardial infarction, and cardiac death. Of 903 patients observed for 4.9 years (median 1.8 years), 570 were diagnosed with MetS. The MetS group displayed more severe coronary artery disease and underwent more extensive PCIs than did the non-MetS group. The overall composite event rate was not significantly different between the MetS and the non-MetS group (11.9% vs 13.2%, p = 0.572). Kaplan-Meier survival analysis showed no significant difference in the event-free survival of the composite event between the 2 groups (p = 0.700). A multivariable Cox regression analysis showed that MetS was not associated with the composite event, whereas total stent length, decreased renal function, diabetes, and the absence of abdominal obesity were associated with the composite event. Abdominal obesity was associated with decreased risk of the composite event, alleviating unfavorable clinical outcomes of patients with diabetes in the MetS group. In conclusion, MetS has no impact on the clinical outcomes of patients who 'underwent PCI with EESs, although the MetS group exhibited more severe coronary artery disease and underwent more extensive PCIs. The paradoxical association between obesity and favorable clinical outcomes may explain this result. (C) 2015 Elsevier Inc. All rights reserved.
This work was supported by a research fund HY-2014-N from the Hanyang University, South Korea.
en
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PERCUTANEOUS CORONARY INTERVENTION
HEART-DISEASE
CARDIOVASCULAR-DISEASE
OBESITY PARADOX
ARTERY-DISEASE
RISK-FACTOR
ANTIPLATELET THERAPY
MASS INDEX
BARE-METAL
MORTALITY
The Impact of Metabolic Syndrome on Clinical Outcomes After Everolimus-Eluting Stent Implantation
Article
5
116
10.1016/j.amjcard.2015.05.041
717-724
AMERICAN JOURNAL OF CARDIOLOGY
Lee, Yonggu
Lim, Young-Hyo
Shin, Jeong-Hun
Park, Jinkyu
Shin, Jinho
Kim, Kyung-Soo
2015001289
S
COLLEGE OF MEDICINE[S]
DEPARTMENT OF MEDICINE
jhs2003