문효방
2017-04-12T07:43:35Z
2017-04-12T07:43:35Z
2015-01
ENVIRONMENT INTERNATIONAL, v. 75, Page. 166-171
0160-4120
1873-6750
http://www.sciencedirect.com/science/article/pii/S0160412014003274
Perchlorate is a widespread environmental contaminant and potent thyroid hormone disrupting compound. Despite this, very little is known with regard to the occurrence of this compound in indoor dust and the exposure of humans to perchlorate through dust ingestion. In this study, 366 indoor dust samples were collected from 12 countries, the USA, Colombia, Greece, Romania, Japan, Korea, Pakistan, Kuwait, Saudi Arabia, India, Vietnam, and China, during 2010-2014. Dust samples were extracted by 1% (v/v) methylamine in water. Analyte separation was achieved by an ion exchange (AS-21) column and analysis was performed by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The overall concentrations of perchlorate in dust were in the range of 0.02-104 mu g/g (geometric mean: 0.41 mu g/g). The indoor dust samples from China contained the highest concentrations (geometric mean: 5.38 mu g/g). No remarkable differences in perchlorate concentrations in dust were found among various microenvironments (i.e., car, home, office, and laboratory). The estimated median daily intake (EDI) of perchlorate for toddlers through dust ingestion in the USA, Colombia, Greece, Romania, Japan, Korea, Pakistan, Kuwait, Saudi Arabia, India, Vietnam, and China was 1.89, 0.37, 1.71, 0.74, 4.90, 720, 0.60, 0.80, 1.55, 0.70, 2.15, and 21.3 ng/kg body weight (bw)/day, respectively. Although high concentrations of perchlorate were measured in some dust samples, the contribution of dust to total perchlorate intake was ˂5% of the total perchlorate intake in humans. This is the first multinational survey on the occurrence of perchlorate in indoor dust. (C) 2014 Elsevier Ltd. All rights reserved.
The authors thank Pierina Maza-Anaya, a youth research fellow supported by the Colombian National Science and Technology System, for helping with dust sample collection from Colombia; Dr. Dilip Kumar Kedia helped with collection of dust samples from India. This study was funded by a grant (1U38EH000464-01) from the Centers for Disease Control and Prevention (CDC, Atlanta, GA) to Wadsworth Center, New York State Department of Health, where the study was conceived and performed. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the CDC.
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PERGAMON-ELSEVIER SCIENCE LTD
Global survey
Human exposure
Indoor dust
Perchlorate
Occurrence of perchlorate in indoor dust from the United States and eleven other countries: Implications for human exposure
Article
75
10.1016/j.envint.2014.11.005
166-171
ENVIRONMENT INTERNATIONAL
Wan, Yanjian
Wu, Qian
Abualnaja, Khalid O.
Asimakopoulos, Alexandros G.
Covaci, Adrian
Gevao, Bondi
Johnson-Restrepo, Boris
Kumosani, Taha A
Malarvannan, Govindan
Moon, Hyo-Bang
2015005635
E
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E]
DEPARTMENT OF MARINE SCIENCE AND CONVERGENCE ENGINEERING
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